Recent Advances in Transcranial Focused Ultrasound (FUS) Triggered Brain Delivery.

Recent Advances in Transcranial Focused Ultrasound (FUS) Triggered Brain Delivery. Curr Drug Targets. 2016 Dec 22; Authors: Nainwal N Abstract Successful delivery of therapeutic agents in the brain is very challenging, which makes treatment of various brain disorders very difficult. One of the major causes of this difficulty is the presence of physiological barriers in the brain like blood brain barrier (BBB) and blood cerebro-spinal fluid (CSF) barrier. These barriers are very specific and restrict the entry of water soluble agents and ionized molecule. Only lipid soluble and small molecular size agents are allowed to enter into the brain. But there are several serious brain diseases in which the use of only conventional small molecular mass lipophilic drug is not effective. Various approaches like the use of BBB permeation enhancers, osmotic disruption of BBB by using mannitol, prodrug approach, etc. have been developed for the transportation of drug across the brain. The current article focuses on the transcranial route, transcranial focused ultrasound (FUS), the techniques involve in transcranial focused ultrasound (FUS) delivery and recent updates of this system. PMID: 28017126 [PubMed - as supplied by publisher]
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research