Synopsis on Managing Strategies for Neurodegenerative Disorders: Challenges from Bench to Bedside in Successful Drug Discovery and Development.

Synopsis on Managing Strategies for Neurodegenerative Disorders: Challenges from Bench to Bedside in Successful Drug Discovery and Development. Curr Top Med Chem. 2016 Dec 22; Authors: Bhat SA, Kamal MA, Ashraf GM Abstract The maintenance of health requires successful cell functioning which in turn depends upon the proper and active conformation of proteins besides other biomolecules. However, occasionally these proteins may misfold and lead to the appearance and progression of protein conformational diseases. These diseases apart from others include several neurodegenerative disorders (NDDs) such as Alzheimer's disease, Parkinson's disease, Huntington disease, multiple sclerosis, amyotrophic lateral sclerosis, and other less well known diseases. Although much knowledge has been gained, these NDDs still warrant advance research in the elucidation of their mechanism as well as effective therapeutic interventions and proper management. There is an ever-growing and urgent need to improve the diagnosis and management of the NDDs due to their devastating nature, serious social impact and neuropsychiatric symptoms. It is also envisioned that we may be able to encourage, develop, and strengthen the cell defenses against amyloid toxicity and prevent neuronal destruction and consequently neurodegeneration. In this review, the implications of protein misfolding and aggregation in NDDs are discussed along with some of the most recent f...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research