Lupin gets USFDA nod for hypertension treatment drug in US

Olmesartan medoximil tablets, generic version of Daiichi Sankyo's Benicar, are indicated for the treatment of hypertension, along with other anti-hypertensive agents.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news

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Purpose of review In 2013, the association between T-Box factor 4 (TBX4) variants and pulmonary arterial hypertension (PAH) has first been described. Now – in 2020 – growing evidence is emerging indicating that TBX4 variants associate with a wide spectrum of lung disorders. Recent findings TBX4 variants are enriched in both children and adults with PAH. The clinical phenotype associated with a TBX4 variant seems to be milder than that in other PAH-associated gene mutations. Further, TBX4 variants have increasingly been associated with a variety of clinical and histopathological phenotypes, including lethal...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: GENETICS: Edited by Coline H.M. van Moorsel Source Type: research
Publication date: Available online 1 April 2020Source: Social Science &MedicineAuthor(s): Patricia East, Jenalee Doom, Erin Delker, Estela Blanco, Raquel Burrows, Paulina Correa-Burrows, Betsy Lozoff, Sheila Gahagan
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
CONCLUSION: The hypertension burden would decrease from 244.5 million persons to 127.5-182.3 million persons in China if the two-visit strategy was applied. PMID: 32224596 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
Conditions:   Hypertension, Essential;   β-hydroxybutyrate Intervention:   Other: dietary restriction (salt restriction) Sponsor:   Sulaiman AlRajhi Colleges Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Resistant Hypertension Interventions:   Drug: Spironolactone;   Drug: Amiloride Sponsor:   Yonsei University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   COVID-19;   Hypertension;   Cardiovascular Diseases Intervention:   Sponsor:   Societa Italiana dell'Ipertensione Arteriosa Recruiting
Source: - Category: Research Source Type: clinical trials
Contributors : Lesha Zhang ; Bing ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusWe utilized high-throughput sequencing and subsequent signaling pathway analyses to find 2 fold change or greater upregulated expression of 230 transcripts and downregulated expression of 165 transcripts in basilar artery smooth muscle cells derived from rats fed a high-salt diet compared with those from control rats.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
Authors: Siegel JD, Ko CJ Abstract Diltiazem is a calcium-channel blocker commonly used for the treatment of hypertension. Common adverse effects include dizziness, headache, and edema. Fewer than 20 cases of diltiazem-associated photodistributed hyperpigmentation have been reported in the literature. Here, we present the case of a 71-year-old woman with new-onset facial hyperpigmentation 6 months after initiating treatment with diltiazem. PMID: 32226335 [PubMed - in process]
Source: The Yale Journal of Biology and Medicine - Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research
Update: On April 1, 2020, the FDA requested manufacturers to withdraw all prescription and over-the-counter (OTC) ranitidine drugs (Zantac, others) from the market immediately, due to the presence of a contaminant known as N-Nitrosodimethylamine (NDMA). Although the FDA did not observe unacceptable levels of NDMA in many of the samples they tested, they have determined that the impurity in some ranitidine products increases over time and when stored at higher than room temperatures. As a result of this recall, ranitidine products will no longer be available for prescription or OTC use in the US. The FDA is also advising co...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Digestive Disorders Drugs and Supplements Source Type: blogs
The EMA have stated that the speculation that ACE-inhibitors or ARBs treatment can make infections worse in the context of COVID-19 is not currently supported by clinical evidence, and they state that there is currently no reason for patients to stop these treatments.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
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