Involvement of ENaC in the development of salt-sensitive hypertension.

Involvement of ENaC in the development of salt-sensitive hypertension. Am J Physiol Renal Physiol. 2016 Dec 21;:ajprenal.00427.2016 Authors: Pavlov TS, Staruschenko A Abstract Salt-sensitive hypertension is associated with renal and vascular dysfunctions which lead to impaired fluid excretion, increased cardiac output and total peripheral resistance. It is commonly accepted that increased renal sodium handling and plasma volume expansion are necessary factors for the development of salt-induced hypertension. The epithelial sodium channel (ENaC) is a trimeric ion channel expressed in the distal nephron which plays a critical role in the regulation of sodium reabsorption in both normal and pathological conditions. In this mini-review we summarize recent studies investigating role of ENaC in the development of salt-sensitive hypertension. Based on experimental data obtained from the Dahl salt-sensitive rats, we and others have demonstrated that abnormal ENaC activation in response to a dietary NaCl load contributes to the development of high blood pressure in this model. The role of different humoral factors, such as the components of the renin-angiotensin-aldosterone system, members of the epidermal growth factors family, Arg-vasopressin and oxidative stress mediating the effects of dietary salt on ENaC are discussed in this review to highlight future research directions, and determine potential molecular targets for drug development. ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research