LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways

In conclusion, our findings reveal a previously unknown regulatory role for LRRK2 in CX3CR1 signalling and suggest that an increase of CX3CR1 activity contributes to the attenuated inflammatory responses in Lrrk2-null microglia.

Source: Human Molecular Genetics - December 22, 2016 Category: Genetics & Stem Cells Authors: Ma, B., Xu, L., Pan, X., Sun, L., Ding, J., Xie, C., Koliatsos, V. E., Cai, H. Tags: ARTICLES Source Type: research