Exhaled breath condensate pH and cysteinyl leukotriens in patients with chronic cough secondary to acid gastroesophageal reflux
Chronic cough is one of the most common clinical problems and it may be secondary to different
stimuli and diseases, including low-level physical and chemical stimulation of the
esophageal –bronchial reflex, suggestive of cough-reflex hyperresponsiveness, in patients with
gastroesophageal reflux; however, it is still debated whether gastroesophageal reflux could induce
airway inflammation and acidification. The aim of this study was to investigate airway pH and
cysteynil-leukotrienes (Cys-LTs) concentration (a marker of airway inflammation) in exhaled breath
condensate (EBC). Patients with chronic cough and for which all known causes, excluding
gastroesophageal reflux, had been investigated and ruled out, were enrolled in the study. All
patients underwent 24 h pH monitoring, and EBC was collected to assess pH and Cys-LTs concentration.
Forty-five patients were included in the study and those with gastroesophageal reflux had
significantly lower EBC-pH and higher concentration of E...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Enrico Heffler, Claudia Crimi, Luisa Brussino, Stefania Nicola, Stefania Sichili, Luca Dughera, Giovanni Rolla and Nunzio Crimi Source Type: research
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