Splenic irradiation for splenomegaly: a systematic review

Symptomatic splenomegaly is a debilitating complication commonly observed in hematologic malignancies and disorders, including chronic lymphocytic leukemia (CLL), myelofibrosis (MF), myeloid metaplasia, lymphoma, prolymphocytic leukemia (PLL), and hairy cell leukemia (HCL). In the US, splenomegaly due to these conditions represents up to 27% of all splenomegaly cases, while common benign causes include liver disease, infection, and congestive splenomegaly.[1] Manifestations of symptomatic splenomegaly include mechanical discomfort, tenderness in the left upper quadrant, early satiety, gastric compression, abdominal bloating, abdominal pain, dyspnea, fatigue, cachexia, and cytopenia secondary to sequestration.
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: General and Supportive Care Source Type: research