Differential Expression of Lipoprotein-Associated Phospholipase A2 in Monocyte Subsets: Impact of Uremia and Atherosclerosis

Conclusion: Uremic environment but not inflammation per se increases plasma Lp-PLA2 activity and ulregulates monocytic Lp-PLA2 mRNA expression. The highest Lp-PLA2 levels were found in the classical and not in the inflammatory subsets. Atherosclerosis also contributes to a subset-specific increase in Lp-PLA2 mRNA expression.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research