Antioxidant and antileukemic activity of chemical components from bark of Mangifera casturi

In this study, antioxidant and antileukemic activity of chemical components from bark ofMangifera casturi was investigated. Research findings have shown that several extracts ofM. casturi have potent bioactivity. The methanol extract ofM. casturi bark was partitioned successively to yieldn-hexane fraction (6.7%), ethyl acetate (EtOAc) fraction (24.1%), andn-butanol (n-BuOH) fraction (28.1%). Five compounds were isolated from EtOAc fraction and one compound was isolated fromn-hexane fraction. These compounds were identified as methyl gallate (1), taxifolin (2), pyrocatechuic acid (3), gallic acid (4), glucogallin (5), and β-sitosterol (6), respectively; they were confirmed by spectroscopic analysis and ultra-performance liquid chromatography-mass spectrometry. All compounds were isolated from bark ofM. casturi for the first time. The EtOAc fraction as well as the isolated gallic acid (4) showed potent antioxidative and antileukemic activity against human leukemia HL-60 cells.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research