DNA-Sensing and Nuclease Gene Expressions as Markers for Colorectal Cancer Progression.

CONCLUSIONS: In contrast to DNA-sensing events in viral infections or autoimmunity, cGAS-STING-IFNB signaling is disrupted in colorectal cancer. The expression levels of cGAS, RNASEH2B, RNASEH2C, and SAMHD1 could be prognostic markers of colorectal cancer.
PMID: 27988520 [PubMed - as supplied by publisher]

Source: Oncology - December 16, 2016 Category: Cancer & Oncology Authors: Yang CA, Huang HY, Chang YS, Lin CL, Lai IL, Chang JG Tags: Oncology Source Type: research