AbbVie Submits New Drug Application to U.S. FDA for its Investigational Regimen of Glecaprevir/Pibrentasvir (G/P) for the Treatment of All Major Genotypes of Chronic Hepatitis C

NORTH CHICAGO, Ill., Dec. 19, 2016 -- (Healthcare Sales &Marketing Network) -- AbbVie (ABBV), a global biopharmaceutical company, announced that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for the company'... Biopharmaceuticals, FDA AbbVie, Glecaprevir, Pibrentasvir, Hepatitis C virus
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news

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The direct-acting antiviral (DAA) combination of glecaprevir and pibrentasvir is effective in patients with genotype 1 hepatitis C virus (HCV) infection after failure of treatment with sofosbuvir plus an NS5A inhibitor, according to results from a new open-label trial.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Introduction: Several studies have shown an association between psoriasis and hepatitis C virus infection. To assess this relationship, we have evaluated the frequency of psoriasis among a population of patients receiving treatment for hepatitis C infection.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
This study aimed to determine whether dose and duration of opioid prescriptions predict subsequent heroin use in United States veterans. We analyzed data from 2002 to 2012 from the Veterans Aging Cohort Study, a prospective cohort study. We used inverse probability of censoring weighted Cox regression to examine the relationship between self-reported past year heroin use and 2 primary predictors: (1) prior receipt of a high-dose opioid prescription (≥90 mg morphine equivalent daily dose), and (2) prior receipt of a long-term opioid prescription (≥90 days). Heroin use was ascertained using most recent value of time-up...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
ConclusionsBehavioral health providers are encouraged to incorporate alcohol use reduce interventions in HIV clinical settings to reduce ART nonadherence among patients living with HIV/HCV coinfection. Additionally, public health professionals and researchers, and clinicians are encouraged to use inductive methods to discover why ART nonadherence disproportionately impacts African American patients living with HIV/HCV coinfection and to develop approaches that are sensitive to those respective barriers.
Source: Journal of Racial and Ethnic Health Disparities - Category: International Medicine & Public Health Source Type: research
AbstractWe contrast three types of abstinence: quit after alcohol associated problems (Q-AP), quit for other reasons (Q-OR), and lifetime abstainer (LTA). We summarized the characteristics of people living with HIV (PLWH), and matched uninfected individuals, by levels of alcohol use and types of abstinence. We then identified factors that differentiate abstinence and determined whether the association with an alcohol biomarker or a genetic polymorphism is improved by differentiating abstinence. Among abstainers, 34% of PLWH and 38% of uninfected were Q-AP; 53% and 53% were Q-OR; and 12% and 10% were LTA. Logistic regressio...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
Abstract The cost-effectiveness of hepatitis C virus (HCV) screening and treatment was examined in low-income, primarily Hispanic baby boomers born 1945-1965 using a Markov model of the natural history of HCV. The model was parameterized using costs and diagnostic data from 2008-2016 and from literature on disease progression and effectiveness of screening and treatment using direct acting anti-viral (DAA) therapy. The incremental cost-effectiveness ratio (ICER) was computed from the perspective of Medicare as payer, calculated over 20 years, and discounted at 3% per year. In the base case, HCV screening cost $3,3...
Source: Journal of Health Care for the Poor and Underserved - Category: International Medicine & Public Health Authors: Tags: J Health Care Poor Underserved Source Type: research
TUESDAY, Aug. 20, 2019 -- Among patients with hepatitis C virus (HCV) infection and complete response to hepatocellular carcinoma (HCC) treatment, direct-acting antiviral (DAA) therapy is associated with a significant reduction in the risk for...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Conditions:   Hepatitis C;   Chronic Hepatitis c;   Hepatitis C, Chronic Intervention:   Other: EC clinic support - whole of practice interventions delivery through nurse-led model Sponsors:   Macfarlane Burnet Institute for Medical Research and Public Health Ltd;   Burnet Institute;   The Alfred;   St Vincent's Hospital Melbourne;   HepatitisVictoria;   Harm Reduction Australia;   Victoria State Government;   Gilead Sciences;   National Health and Medical Research C ouncil, Australia Recruiting
Source: - Category: Research Source Type: clinical trials
Publication date: Available online 19 July 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Suresh Gorka, Ghulam M. Gulzar, Ghulam N. Yattoo, Jaswinder S. Sodhi, Gulzar A. Dar, Mushtaq A. Laway, Saurabh Kaushik, Neeraj Dhar, Syed Mushfiq, Riffat A. AzizBackgroundOur data is one of the earliest study from the Indian subcontinent on Velpatasvir/Sofosbuvir (VEL/SOF) combination in chronic hepatitis C (CHC). The primary end point was to evaluate sustained virologic response (SVR) 12 in CHC-infected patients and to determine its effect in patients with hepatitis C virus–related cirrhosis. The sec...
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
This study aimed to investigate whether the HCV genotype affected the surv...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
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