Generation of endoderm lineages from pluripotent stem cells.

Generation of endoderm lineages from pluripotent stem cells.
Regen Med. 2016 Dec 15;
Authors: Luo X, Wang H, Leighton J, O'Sullivan M, Wang P
Abstract
Definitive endoderm is the cellular precursor to respiratory- and digestive-related organs such as lungs, stomach, liver, pancreas and intestine. Endodermal lineage cells derived from pluripotent stem cells (PSCs) in vitro are a potentially unlimited resource for regenerative medicine. These cells are useful tools for studying the physiology, pathogenesis and medical therapies involving these tissues, and great progress has been achieved in PSCs differentiation protocols. In this review, we will focus on the most common and/or advanced differentiation strategies currently used in generating endodermal lineage cells from PSCs. A brief discussion about the effect of early definitive endoderm differentiation on the final development products will follow.
PMID: 27976977 [PubMed - as supplied by publisher]

Source: Regenerative Medicine - December 14, 2016 Category: Genetics & Stem Cells Authors: Luo X, Wang H, Leighton J, O'Sullivan M, Wang P Tags: Regen Med Source Type: research