Avoiding over-the-counter heartburn medications could save cancer patients' lives

Something as seemingly harmless as a heartburn pill could lead cancer patients to take a turn for the worse. A new study has discovered that proton pump inhibitors, which are very common medications for heartburn and gastrointestinal bleeding, decrease effects of capecitabine, a type of chemotherapy usually prescribed to gastric cancer patients.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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ConclusionsFOSL1 is an independent prognostic biomarker of GC. Detecting FOSL1 expression could help stratify GC patients with high-risk and guide the precious treatment.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
In this study, we aimed to investigate the role of IL-6/Stat3 signaling pathway in human endometrial cancer cells invasion and migration. We demonstrated that Stat3 is activated in endometrial cancer cell lines. To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6. Furthermore, we showed that Stat3 inhibitor significantly decreased the expression of MMP2 enhanced by IL-6, indicating that IL-6 promoted endometrial cancer invasion and migration by Stat3-in...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 19 March 2019Source: Pathology - Research and PracticeAuthor(s): Xiaobo He, Ying ShuAbstractIncreasing evidence has shown that dysregulation of mircoRNA (miRNA) is linked to the development and progression of human cancer, including gastric cancer (GC). In the current study, by analysing the GEO database (GSE78091), we found that miR-660 was significantly downregulated in GC. Consistently, quantitative real-time PCR (qRT-PCR) results showed that miR-660 was dramatically decreased in GC tissues and cell lines. Importantly, low miR-660 expression was closely related to larger tumor size (P&...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionsThe results pointed out that the high expression of miR-106b-5p serves as an independent factor for predicting the worse prognosis of RCC patients.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
In conclusion, clinical presentation at time of diagnosis of brain metastases consistently includes neurologic signs and symptoms with persistent headache being the most common. Endometrial cancer patients that present with new neurologic complaints or exam findings should be evaluated for brain metastases.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
We describe a case of an 80-year-old woman with ovarian metastasis of MCC six years after excision of a cutaneous MCC on the cheek.DiscussionTo our knowledge only three cases with ovarian metastasis of MCC have been described so far. Our case is the second with distant metastasis to the ovary spreading from a primary tumor in the skin of the head, in the other two cases the primary tumor was in the inguinal skin.ConculsionMCC is a highly aggressive cutaneous and mucosal malignancy with frequent recurrence, lymph node and distant metastases. There is no clear consensus how to treat metastatic disease.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
In states that legalized medical marijuana, there was a 4.8 percent decrease in reported pain for conditions that qualified for pot treatment (cancer, arthritis, glaucoma and pain), compared to states without medical marijuana.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Conclusion This larger set of observational data finds that PPI drugs are associated with an increase in the risk of early death compared with either H2 blockers or no acid suppression drugs. This was the case for participants both with and without gastrointestinal problems. It also appears as though the longer the PPIs drugs are taken, the greater the risk of death. Considering that these drugs are widely used in the UK, these findings may cause concern. But the research has a number of important limitations: The study was conducted in a population of mostly white, older US male veterans, which might limit the abi...
Source: NHS News Feed - Category: Consumer Health News Tags: Medication Source Type: news
In 1982, two Australian scientists discovered that a certain bacterium, Helicobacter pylori, was a common cause of persistent stomach inflammation and stomach ulcers. This realization revolutionized ulcer treatment. While fairly common, this infection usually causes no symptoms, but it can sometimes lead to ulcers in the stomach or the very first part of the small intestine (duodenum), and to certain types of stomach cancer. There is also evidence linking H. pylori infection to other conditions like iron-deficiency anemia and vitamin B12 deficiency. The bacteria are thought to spread through contaminated water, vomit, or f...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Digestive Disorders Health Infectious diseases Tests and procedures Source Type: blogs
The post I still don’t think it is necessary! – Sian’s story appeared first on Hysterectomy Association. Well, as you will see, the title of my story isn’t strictly true, but my journey started when I went to my GP with slight menopausal bleeding. It took me a few days to decide whether it was bleeding or just slightly coloured discharge, however, she told me that they always refer anyone over 60 with post menopausal bleeding to the aptly named ‘post menopausal bleeding clinic’! I was out enjoying a meal with friends, when I received a phone call from the clinic inviting me in for a cons...
Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Your Stories cancer Source Type: news
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