Reply: Understanding vascular calcification from an evolutionary approach

Understanding the evolutionary mechanisms that support the development of vascular calcification is a valid point, and one that may ultimately reveal novel etiologies of this complex vascular remodeling process [1]. Nonetheless, the overall supposition that vascular calcification occurs as a consequence of atherosclerosis (owing to the relatively late appearance of atherosclerosis in the history of man) may be an overly simplistic interpretation of the (mal)adaptive consequences of calcifying blood vessels.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Tags: Letter to Editor Source Type: research