Long-term painkiller use 'linked to hearing loss in women'
Conclusion Many people use medicines like paracetamol or ibuprofen for aches and pains. There's no suggestion from this study that occasional use to manage a headache or muscle strain is harmful. But the study is a reminder that regular use – defined by the researchers as two days or more a week – could have health consequences over time. However, this study has some limitations. As a cohort study, it can't prove cause and effect between paracetamol and NSAIDs and hearing loss. And it mainly included white women, all in the US, so we don't know if the results apply to other groups. Also, the increased risk was small – as there's no information about some factors that can also affect hearing, such as exposure to loud noise, it's possible unmeasured confounding factors might have explained the link. As hearing loss was not measured by hearing tests but just by asking people if they'd had hearing problems, it is subject to further diagnostic uncertainty. Overall, however, this study adds to previous evidence that the regular use of paracetamol and NSAID medicines could be a factor in some cases of hearing loss. It makes sense to limit your use of these drugs to when they're needed. If you find you have to take painkillers on several days a week, it's probably a good idea to talk to your doctor about what's causing the pain and whether there are better ways to manage it. Hearing loss is common as people get older. There are ways to protect your hearing&n...
The Pallimed community is invited to participate in the #hpm Tweet Chat this week which help inform and shape a comparative effectiveness research proposal being designed by the Brain Cancer Quality of Life Collaborative, an initiative led by a team of patients, care partners, advocates, neuro-oncologists, and palliative care professionals.The #hpm Tweet Chat is this Wednesday, April 25th, 6-7p PST/9-10p ET.Topics for the chatare available here, in the #hpm chat ’s blog post,How might we introduce palliative care to people with complex neurological conditions, by Liz Salmi and Bethany Kwan, P...
This study included all patients with non-metastatic primary T1 UBC reported to the Swedish National Register of Urinary Bladder Cancer (SNRUBC) from 1997 to 2014, excluding those treated with primary cystectomy. Differences between groups were evaluated using chi-squared tests and logistic regression, and survival was investigated using Kaplan-Meier and log-rank tests and Cox proportional hazards analysis. RESULTS: In all, 7681 patients with T1 UBC (77% male, 23% female) were included. Females were older than males at the time of diagnosis (median age at presentation 76 and 74 years, respectively; p
Conclusion: Our results support the hypothesis of widespread impairment resulting from alcohol consumption. The recovery of cognitive functions is not homogeneous during prolonged abstinence. PMID: 29674602 [PubMed - as supplied by publisher]
It appears the prescribing of Subsys in non-cancer patients is now considered a crime by the federal government. Las Vegas pain physician arrested for illegal fentanyl distribution: 5 things to know Written by Brian Zimmerman | February 19, 2018 www.beckershospitalreview.com Police arrested a Las Vegas pain management physician Feb. 13 for charges related to the unlawful distribution of fentanyl and healthcare fraud. Here... Subsys Rx for Non-cancer Patients Is Considered a Criminal Act
Authors: Gao Y, Xu Y, Wang J, Yang X, Wen L, Feng J Abstract Long noncoding RNAs (lncRNAs) have been acknowledged as important regulators in various human cancers. LncRNA MNX1-AS1has been shown to be an oncogene in epithelial ovarian cancer. However, the function of MNX1-AS1 in glioblastoma (GBM) remains largely unknown. Here, we found that the expression of MNX1-AS1 was significantly upregulated in GBM tissues and cell lines. Knockdown of MNX1-AS1 significantly inhibited the proliferation, migration and invasion of GBM cells. In terms of mechanism, we found that MNX1-AS1 could bind to miR-4443 in GBM cells. Overex...
This study also identified cordycepin derivatives with promising pharmacological and pharmacokinetic properties for further investigation in the development of new treatments for endometrial cancer. PMID: 29673423 [PubMed - as supplied by publisher]
Authors: Wang L, Li Q, Ye Z, Qiao B Abstract Renal carcinoma greatly threatens human health, but the involved molecular mechanisms are far from complete understanding. As a master oncogene driving the initiation of many other cancers, Pokemon has not been established to be associated with renal cancer. Our data revealed that Pokemon is highly expressed in renal carcinoma specimen and cell lines, compared with normal cells. The silencing of Pokemon suppressed the proliferation and invasion of renal cancer cells. Pokemon overexpression rendered normal cells with higher proliferation rates and invasiveness. Animal stu...
Conclusion Low dose of acacetin from 10^-3 μM to 1 μM promoted the proliferation of MCF-7 cells through the ERK/PI3K/AKT pathway and its downstream cyclin signaling, and this pathway is mainly mediated by the expression of ERα. PMID: 29676234 [PubMed - as supplied by publisher]
Authors: Iqbal A, Novodvorsky P, Heller SR Abstract This corrects the article on p. 3 in vol. 42, PMID: 29504302. PMID: 29676550 [PubMed]
Authors: Cho NH, Kim HS PMID: 29676549 [PubMed]
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