Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function

Conclusions
We demonstrated that LPP3 is a negative regulator of inflammatory cytokines, leucocyte adhesion, cell survival, and migration in HAECs, suggesting a protective role of LPP3 against endothelial dysfunction in humans. Both the catalytic and the RGD functional domains were involved and S1P, but not LPA, might be the endogenous substrate of LPP3.

Source: Cardiovascular Research - December 14, 2016 Category: Cardiology Authors: Touat-Hamici, Z., Weidmann, H., Blum, Y., Proust, C., Durand, H., Iannacci, F., Codoni, V., Gaignard, P., Therond, P., Civelek, M., Karabina, S. A., Lusis, A. J., Cambien, F., Ninio, E. Tags: Vascular biology Source Type: research