Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning

Conclusions These data strongly suggest that GLP-1 functions as a humoral factor of remote ischaemic conditioning cardioprotection. This phenomenon requires intact vagal innervation of the visceral organs and recruitment of GLP-1R-mediated signalling. Cardioprotection induced by GLP-1R activation is mediated by a mechanism involving M3 muscarinic receptors.

http://cardiovascres.oxfordjournals.org/cgi/content/short/112/3/669?rss=1

Source: Cardiovascular Research - December 14, 2016 Category: Cardiology Authors: Basalay, M. V., Mastitskaya, S., Mrochek, A., Ackland, G. L., del Arroyo, A. G., Sanchez, J., Sjoquist, P.-O., Pernow, J., Gourine, A. V., Gourine, A. Tags: Cardiac biology and remodelling Source Type: research