Attractive drug candidate identified to target glioma brain tumors

(University of Alabama at Birmingham) In a paper published in Cancer Research, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed. The inhibitor, GA11, retains a core structure that resembles natural inhibitors of the biomarker enzyme; but it has been modified to help it pass through the blood-brain barrier.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news