Two new labdane diterpenoids and one new β-lactam from the aerial parts of Roylea cinerea

Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Reena Sharma, Sona Mohammadi-Ostad-Kalayeh, Frank Stahl, Carsten Zeilinger, Gerald Dräger, Andreas Kirschning, P.C. Ravikumar Two new labdane diterpenoids cinereanoid C (1), cinereanoid D (2), a new β-lactam, cinerealactam E (3) as well as six known flavonoid glycosides (4–9) were isolated from the aerial parts of Roylea cinerea (Lamiaceae). The structures of (1–9) were all determined by MS, IR and NMR spectroscopy. The structure of cinereanoid D (2) was further proven by single crystal X-ray diffraction. Six known flavonoid glycosides (4–9) were also isolated for the first time from this plant. 2, 5, 6 and 7 were found to significantly inhibit the ATP binding of a tumour growth-promoting heat shock protein, Hsp90. Graphical abstract

Source: Phytochemistry Letters - December 14, 2016 Category: Chemistry Source Type: research