Process Intensification of Tetrazole reaction through tritylation of 5-[4 ′-(Methyl) Biphenyl-2-Yl] using micoreactors

Publication date: Available online 14 December 2016 Source:Chemical Engineering and Processing: Process Intensification Author(s): Yadagiri Maralla, Shirish Sonawane, Dhurke Kashinath, Makarand Pimplapure, Banoth Paplal Currently, process intensification research is focused on use of the continuous micro reactor over the batch reactors. The micro reactor process gives continuous product output, effective micro mixing and better yield in small residence time over batch reactors. A continuous flow process has been successfully developed for the tritylation of 5-(4'-methyl-[1,1′-biphenyl]-2-yl)-1H-tetrazole [MBPT] using different microreactors. The reaction was carried out in three different configurations of microreactors. The SSCR–1mm and 2mm (Stainless steel capillary coil micro reactors) gives yield of 93.72 and 92.87% for the residence time of 71s and 324s respectively. Among the three microreactors, Corning® AFR afforded effectively higher yield (95.18%) for the residence time of 27s. Thus, 5-(4'-methyl-[1,1′-biphenyl]-2-yl)-1-trityl-1H-tetrazole, a useful intermediate material for some of the pharmaceutical products that can be produced industrially using microreactor. Graphical abstract

Source: Chemical Engineering and Processing: Process Intensification - December 14, 2016 Category: Chemistry Source Type: research