Accelerating Medicines Partnership (AMP) in Type 2 Diabetes (U01)

Funding Opportunity RFA-DK-14-003 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for the Accelerating Medicines Partnership (AMP) in Type 2 Diabetes (T2D-GENES) consortium. The AMP T2D-GENES will build on and expand the previous work of the T2D GENES consortium. The aim of the consortium is to characterize the genetic variations in human genomic regions that have been putatively associated with type 2 diabetes (T2D) and conduct follow-up functional studies of particular genetic variants. The data coordinating center for the consortium is being solicited via the companion FOA.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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Authors: Liu J, Yang L Abstract Effects of propofol and sevoflurane on blood glucose, hemodynamics, and inflammatory factors of patients with type 2 diabetes mellitus (T2DM) and gastric cancer (GC) were investigated. One hundred and ten patients with T2DM and GC, treated in The First Affiliated Hospital of Baotou Medical College (Baotou, China) from January 2017 to December 2018, were selected. Sixty patients anesthetized by propofol were included in the propofol group, whereas 50 patients anesthetized by sevoflurane were included in the sevoflurane group. The level of blood glucose, hemodynamic indicators, and inf...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, endogenous ghrelin system could be considered as a new target or treatment for metabolism disorders, cardiac diseases, neurodegenerative diseases, and tissue injuries.
Source: Peptides - Category: Biochemistry Source Type: research
Publication date: Available online 23 January 2020Source: Pharmacological ResearchAuthor(s): Shabnam Radbakhsh, Thozhukat Sathyapalan, Maciej Banach, Amirhossein SahebkarAbstractMicroRNAs (miRNA) are one class of the small regulatory RNAs that can impact the expression of numerous genes including incretin hormones and their G protein-coupled receptors. Incretin peptides, including GLP-1, GLP-2, and GIP, are released from the gastrointestinal tract and have an crucial role in the glucose hemostasis and pancreatic beta-cell function. These hormones and their analogs with a longer half-life, glucagon like peptide-1 receptor a...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
This study investigated whether RIPreC and RIPostC exerted neuroprotection against cerebral ischemic injury in type 2 diabetic mice. RIPreC (24 h before ischemia) and RIPostC (immediately after reperfusion) were performed in an ischemia/reperfusion induced stroke model with type 2 diabetes. Ischemic outcomes, flow cytometry, multiplex cytokine assay, and western blotting were analyzed after 45 min of ischemia followed by 48 h of reperfusion. Our data indicated that RIPreC and RIPostC attenuated cerebral injuries and neurological deficits. RIPreC significantly reduced CD4 T cell and CD8 T cell infiltration and increas...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Authors: Tieri M, Ghelfi F, Vitale M, Vetrani C, Marventano S, Lafranconi A, Godos J, Titta L, Gambera A, Alonzo E, Sciacca S, Riccardi G, Buscemi S, Del Rio D, Ray S, Galvano F, Beck E, Grosso G Abstract Whole grains have been associated with a number of health benefits. We systematically reviewed existing meta-analyses of observational studies and evaluated the level of evidence for their putative effects based on pre-selected criteria. Of the 23 included studies, we found convincing evidence of an inverse association between whole grain consumption and risk of type-2 diabetes and colorectal cancer; possible evid...
Source: International Journal of Food Sciences and Nutrition - Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research
Condition:   Diabetes Mellitus, Type 2 Interventions:   Drug: Metformin and Glimepiride (Low Dosage);   Drug: Metformin and Vildagliptin (Low Dosage);   Drug: Metformin and Insulin Glargine U100 (Low Dosage);   Drug: Metformin, Insulin Glargine U100, and Human Regular Insulin (Low Dosage);   Drug: Metformin and Glimepiride (Regular  Dosage);   Drug: Metformin and Vildagliptin (Regular Dosage);   Drug: Metformin and Insulin Glargine U100 (Regular Dosage);   Drug: Met...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The majority of doctors will tell you that there is nothing you can do to reverse fatty liver and that health problems such as cirrhosis and liver failure may be in your future that they will address with the awful “solution” of liver transplant. The truth is the opposite: fatty liver is easily and readily reversible in virtually everybody, provided you take action before irreversible changes take place and are given the right information and tools. In this video, I discuss the three basic phenomena that drive fat deposition, liver damage, and inflammation that lead to this condition: Carbohydrate consumption ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open bowel flora carbohydrates carbs Inflammation NAFLD nash triglycerides undoctored wheat belly Source Type: blogs
Funding Opportunity RFA-DK-20-501 from the NIH Guide for Grants and Contracts. The purpose of this Limited Competition Funding Opportunity Announcement (FOA) is to continue follow-up of the Diabetes Prevention Program Outcomes Study (DPPOS) cohort through a collaborative cooperative agreement. The Diabetes Prevention Program (DPP) was a multi-center controlled clinical trial examining the efficacy of treatments to prevent or delay the development of type 2 diabetes in a population at high risk. The DPP demonstrated that either weight loss through lifestyle change or the drug metformin could reduce the development of type ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Funding Opportunity RFA-DK-20-502 from the NIH Guide for Grants and Contracts. The purpose of this Limited Competition Funding Opportunity Announcement (FOA) is to continue follow-up of the Diabetes Prevention Program Outcomes Study (DPPOS) cohort through a collaborative cooperative agreement. The Diabetes Prevention Program (DPP) was a multi-center controlled clinical trial examining the efficacy of treatments to prevent or delay the development of type 2 diabetes in a population at high risk. The DPP demonstrated that either weight loss through lifestyle change or the drug metformin could reduce the development of type ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Researchers here propose that the skin is a significant source of the systemic chronic inflammation that is observed in older individuals. Setting aside the range of other mechanisms that contribute to inflammation to only consider the accumulation of senescent cells with age, and the fact that these errant cells are a potent source of inflammatory signaling, this proposition doesn't seem unreasonable. The skin is a sizable organ, after all, and even if it produces senescent cells at much the same pace as the rest of the body, it will still represent a large and quite distributed pool of such cells, positioned to delivery ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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