Relationship between expression of vascular endothelial growth factor and the proliferation of prolactinomas

Prolactinomas are the most common functional hormone-producing pituitary lesions, accounting for 30-40% of all pituitary tumors [1 –4], while in autopsy series their incidence reaches 50% [5]. Between the ages of 20 and 50 years, they are more common in females than males. Above the age of 50 years, they are equally prevalent in each gender [6]. Symptoms of hyperprolactinemia consist of decreased libido, galactorrhea, gynecom astia, amenorrhea, and infertility. Large macroprolactinomas can cause additional symptoms by compressing nearby structures, including headache,palsies of cranial nerves,optic neuropathy and visual field cuts.
Source: Clinical Neurology and Neurosurgery - Category: Neurosurgery Authors: Source Type: research