Biotransformation of 20(R)-panaxatriol by Aspergillus niger AS 3.739

Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Yan Song, Jie Li, Sensen Yan, Haijun Lin, Jianlin Li, Juanjuan Wu, Xuguang Zhai, Guangtong Chen Microbial transformation of 20(R)-panaxatriol (PT) was performed by using the fungus Aspergillus niger AS 3.739. Six metabolites (1–6) including five new compounds were obtained. The chemical structures of these transformed products were elucidated based on various spectroscopic analyses, including 1D and 2D NMR and HRESI-MS. Metabolites 2–6 are new compounds. Furthermore, metabolites 2, 3, 5, and 6 exhibited significant anti-hepatic fibrosis activity, while 4 showed cytotoxicity against HSC-T6 cells. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research