Renal, metabolic and cardiovascular considerations of SGLT2 inhibition

Nature Reviews Nephrology 13, 11 (2017). doi:10.1038/nrneph.2016.170 Authors: Ralph A. DeFronzo, Luke Norton & Muhammad Abdul-Ghani The kidney has a pivotal role in maintaining glucose homeostasis by using glucose as a metabolic fuel, by producing glucose through gluconeogenesis, and by reabsorbing all filtered glucose through the sodium–glucose cotransporters SGLT1 and SGLT2 located in the proximal tubule. In patients with diabetes, the
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Review Source Type: research