Follicular lymphoma: A tale of 2 cancers

(PLOS) Many people survive well beyond 10 years following diagnosis of follicular lymphoma. Yet in a small number of cases, histological transformation -- where fast-growing cells outnumber the smaller, slow-growing cells -- or early progression to aggressive lymphoma occurs. In a study published in PLOS Medicine, Sohrab Shah and colleagues from the BC Cancer Agency in Vancouver, Canada, show that disparate evolutionary trajectories and mutational profiles drive these two distinct clinical endpoints.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news