Comparison of Biomechanical and Histological Outcomes of Different Suture Techniques in Rat Rectus Abdominis Muscle Repair

Abstract: The aim of this study was to determine the strongest suture technique that retains the most muscle thickness to obtain functional outcome for Sprague–Dawley rat rectus abdominis muscle repair. We exposed the paired rectus abdominis muscle of 32 Sprague–Dawley rats on both sides (n = 64) and cut transversely. Immediate closure of the muscle was performed using one of 4 different suture methods (group A: interrupted suture, group B: horizontal mattress suture, group C: vertical mattress suture, group D: overlapping suture). After 8 weeks, the sutured muscle was dissected and cut for evaluation of tensile strength and muscle thickness. Histologic findings were evaluated using automatic quantitative component image analysis software (i-Solution) and immunohistochemical staining using CD31. P values were based on the Mann–Whitney test and Bonferroni correction. Group A showed the strongest tensile strength (P
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Research Source Type: research