Glaukos touts IOP reduction in pseudophakic iStent study

Glaukos (NYSE:GKOS) today released data from a study of its iStent trabecular micro-bypass stent, touting reduced intraocular pressure when implanted in pseudophakic eyes with open-angle glaucoma. Data from the study was recently published in the Journal of Glaucoma, the Laguna Hills, Calif.-based company said. Glaukos’ iStent micro-bypass stents are made from non-ferromagnetic titanium and coated in heparin, is designed to be implanted into multiple trabecular meshwork through a single corneal entry point to reduce IOP, the company said. Pseudophakic eyes are eyes in which the natural lens has been removed and replaced with an intraocular lens. Data from the retrospective, consecutive case series explored outcomes in 42 procedures in which the iStent device was implanted in pseudophakic eyes with preoperative mean intraocular pressures of 20.26 mm Hg. After 2 years, 21 eyes treated with the iStent reported a mean medicated IOP decrease of 6.64 mm Hg, down 33% A total 96% of patients with preoperative medicated IOP of greater than or equal to 19 mm Hg reported a reduction in IOP on their last follow-up. Only 1 patient required additional glaucoma surgery, Glaukos said, commenting that the “safety profile was favorable.” “While multiple studies and years of real-world experience have demonstrated the ability of iStent to achieve sustained IOP reductions when used in combination with cataract surgery, we wanted to explore the IOP...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Clinical Trials Optical/Ophthalmic Glaukos Source Type: news

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Conclusions: Our 5-year clinical results of nDSAEK and DSAEK did not show significant differences at almost all points.
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
ConclusionsWhen indirectly comparing alternative MIGS methods combined with cataract surgery, the option of two trabecular micro-bypass stents showed both a superior efficacy and long-term cost –utility from a German perspective. Moreover, outcomes of the disease-transition model suggest POAG patients to beneficiate the most from an earlier intervention in the moderate stage contrary to waiting until an advanced disease is present.
Source: International Ophthalmology - Category: Opthalmology Source Type: research
Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma. Cochrane Database Syst Rev. 2020 Mar 09;3:CD012740 Authors: Otarola F, Virgili G, Shah A, Hu K, Bunce C, Gazzard G Abstract BACKGROUND: Glaucoma is a leading cause of irreversible blindness. A number of minimally-invasive surgical techniques have been introduced as a treatment to prevent glaucoma from progressing; ab interno trabecular bypass surgery with the Schlemm's canal Hydrus microstent is one of them. OBJECTIVES: To evaluate the efficacy and safety of ab interno trabecular bypass su...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
No abstract available
Source: Journal of Glaucoma - Category: Opthalmology Tags: Online Articles: Letters to the Editor Source Type: research
This article reports the case of a 57-year-old woman with endophthalmitis associated with Abiotrophia defectiva 3 months after uncomplicated cataract surgery combined with the implantation of a glaucoma gel-stent in the right eye. The patient had complained of redness of the right upper nasal conjunctiva and pain for 2 weeks prior to the endophthalmitis. A topical steroid eyedrop treatment without antibiotic additives had temporarily improved the situation. The patient presented with hypopyon, acute deterioration of vision and severe periocular pain of the right eye since the early morning. The gel-stent had...
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
ConclusionThe 1-year postoperative results suggest that P-ExPRESS is as effective as P-Trab, with fewer complications.
Source: International Ophthalmology - Category: Opthalmology Source Type: research
CONCLUSION: This study showed that the gonioscopy-assisted transluminal trabeculotomy procedure is an effective and minimally invasive form of glaucoma surgery. Its effect was related to intraoperative blood in Schlemm's canal. PMID: 32090607 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
In this study, we report on successful in vivo measurements of intraocular pressure in rabbits using an optical IOP measurement system. The sensor was implanted during cataract surgery in two New Zealand white (NZW) rabbits and tested in vivo for ten weeks. Prior to implantation, the sensors were characterized in vitro in the physiologically relevant pressure range of 0–60 mmHg. A portable wireless handheld reader consisting of an internal beam splitter, a monochromatic light source, and a digital single-lens reflex (DSLR) camera was also designed and implemented to capture interference patterns from the sensor. The ...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Abstract A congenital cataract is a rare disorder, which is associated with a high risk of amblyopia. Ophthalmologists are faced with many diagnostic and surgical challenges in the management of this disease. Older children can undergo primary treatment with an intraocular lens, whereas children younger than 12 months of age usually initially remain aphakic. The most frequent long-term complication of aphakic eyes following congenital cataract surgery in connection with posterior capsulorrhexis and anterior vitrectomy is aphakic glaucoma, which in individual cases can lead to substantial impairment ...
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
CONCLUSION: The 3-month postoperative refractive and visual outcomes were comparable between FLACS and CPS in paired eyes from the same patients. Complication rate was low in the study population. PMID: 32066559 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
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