'Rewired' cells show promise for targeted cancer therapy
(Northwestern University) A major challenge in truly targeted cancer therapy is cancer's suppression of the immune system. Northwestern University synthetic biologists now have developed a general method for 'rewiring' immune cells to flip this action around. When cancer is present, molecules secreted at tumor sites render many immune cells inactive. The Northwestern researchers genetically engineered human immune cells to sense the tumor-derived molecules in the immediate environment and to respond by becoming more active, not less.
Publication date: Available online 17 July 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Duarte de Melo-Diogo, Rita Lima-Sousa, Cátia G. Alves, Elisabete C. Costa, Ricardo O. Louro, Ilídio J. CorreiaAbstractGraphene family nanomaterials’ (GFN) ability to interact with near-infrared light has propelled their application in cancer photothermal therapy. Furthermore, the graphitic lattice of GFN can adsorb different types of molecules, which has motivated their use in cancer drug delivery. However, the direct application of GFN in cancer therapy is severely hindered by their poor colloidal st...
This study identified a previously unrecognized regulatory axis between AHR and polyamine metabolism and discovered clofazimine as an inhibitor of AHR and a potentially clinically-relevant anti-multiple myeloma agent.RNA-seq: human multiple myeloma MM1S and human normal fibroblasts WI38 cells -/+ CLF 2-4uM for 24hrs; -/+ shAHR
(Wiley) Previous research has shown that cannabinoids can help lessen side effects of anti-cancer therapies. Now a new British Journal of Pharmacology review has examined their potential for the direct treatment of cancer.
SummaryMicrotubule as an important target in the cancer therapy was used to design novel tubulin polymerization inhibitors. Sulfanilamide-1,2,3-triazole hybrids were designed by a molecular hybridization strategy and their antiproliferative activity against three selected cancer cell lines (BGC-823, MGC-803 and SGC-7901) were evaluated. All sulfanilamide-1,2,3-triazole hybrids displayed potent inhibitory activity against all cell lines. In particular, compound10b showed the most excellent inhibitory effect against MGC-803 cells, with an IC50 value of 0.4 μM. Cellular mechanism studies elucidated that10b induced apoptosi...
Treatment costs for the immunotherapy can run to more than $1 million. Some state Medicaid programs aren't paying for the treatment, and Medicare's complicated payment rates have hospitals worried.(Image credit: Fanatic Studio/Collection Mix: Subjects RF/Getty Images)
Conclusion: Our results indicate that SirT1 regulates apoptosis and radiation sensitization in lung cancer cell lines A549 and H460 via the SirT1/NF- κB/Smac pathway.Cell Physiol Biochem 2018;48:304 –316
Xingming Deng, Zhuofei Li, Guan Li, Bei Li, Xinhan Jin, Guoqing Lyu
There have been significant and continued improvements in the treatment for and survival from childhood cancer over the past few decades. Based on Australian and overseas statistics, the 5 year survival rates have improved to approximately 80% and the majority of these children will go on to become long term survivors (Baade et al., 2010; Gatta et al., 2009; Miller et al., 2016; Ries et al., 2008). Accompanying this increased survival, long-term physical and psychological consequences of cancer therapy are becoming more apparent.
Conclusion: Molecular mechanism and clinical efficacy of some of the emerging molecular targets for cancer chemotherapy have been briefly reviewed in the present article.
Cardiorenal complications of immune checkpoint inhibitors, Published online: 16 July 2018; doi:10.1038/s41581-018-0035-1Immune checkpoint inhibitors (ICIs) have led to a paradigm shift in cancer therapy; however, these agents can induce immune-related adverse events (irAEs) in off-target organs. This Review describes the mechanism of action of ICI therapies and how these agents induce irAEs in the kidney and heart.