What Are Some Criteria For Varicocele Evaluation?
Discussion Varicoceles are caused by high venous back pressure which causes a tortuous dilatation of the testicular veins (pampiniform plexus) of the spermatic cord. They occur more on the left than right because the left renal vein has a higher pressure than the inferior vena cava which drain the left and right gonadal veins respectively. Varicoceles are not very common in young children (3% in
Publication date: Available online 18 April 2019Source: Stem Cell ReportsAuthor(s): Fani Papagiannouli, Cameron Wynn Berry, Margaret T. FullerSummaryTissue homeostasis and repair relies on proper communication of stem cells and their differentiating daughters with the local tissue microenvironment. In the Drosophila male germline adult stem cell lineage, germ cells proliferate and progressively differentiate enclosed in supportive somatic cyst cells, forming a small organoid, the functional unit of differentiation. Here we show that cell polarity and vesicle trafficking influence signal transduction in cyst cells, with pro...
Authors: Conte SC, Spagnol G, Biolo M, Confalonieri M Abstract The conventional-trans bronchial needle aspiration (c-TBNA) has been the first procedure for sampling hilar/mediastinal lymph node for the diagnosis/staging of lung cancer. In the last decade the endobronchial ultrasound trans bronchial needle aspiration (EBUS-TBNA) was introduced in clinical practice and became the first-choice exam in diagnosis and staging of lung cancer. The aim of this study was to compare the diagnostic accuracy (DA), sensitivity and adequacy of c-TBNA and EBUS-TBNA. It was a retrospective and observational multicenter study. The f...
Publication date: 18 April 2019Source: Cell, Volume 177, Issue 3Author(s): Xiao Tian, Denis Firsanov, Zhihui Zhang, Yang Cheng, Lingfeng Luo, Gregory Tombline, Ruiyue Tan, Matthew Simon, Steven Henderson, Janine Steffan, Audrey Goldfarb, Jonathan Tam, Kitty Zheng, Adam Cornwell, Adam Johnson, Jiang-Nan Yang, Zhiyong Mao, Bruno Manta, Weiwei Dang, Zhengdong ZhangSummaryDNA repair has been hypothesized to be a longevity determinant, but the evidence for it is based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel of 18 rodent species with diverse lifespans, we show that more robust DNA doubl...
Publication date: Available online 19 April 2019Source: The Annals of Thoracic SurgeryAuthor(s): Akiko Tanaka, Sam D. Leonard, Harleen K. Sandhu, Rana O. Afifi, Charles C. Miller, Kristofer M. Charlton-Ouw, Amberly Ray, Madiha Hassan, Hazim J. Safi, Anthony L. EstreraAbstractBackgroundThe purpose of this study was to redefine indications of open descending and thoracoabdominal aortic aneurysm (D/TAAA) repair in the younger population.MethodsBetween 1991 and 2017, 2012 patients undergoing D/TAAA at our institution were divided into two groups for comparison: younger (
Infertility and diminished fertility are relevant to pediatric populations, but only beginning to be explored and clinically managed systematically in pediatric settings. This is a significant issue, one that impacts a wide variety of pediatric patients, and complex in abundance of ways. Conceiving and/or giving birth to genetic children is only possible after the onset of puberty and typically occurs volitionally only well after that. However, pediatric patients and their families often need to grapple with fertility concerns well in advance of late adolescence and/or adulthood.
Authors: Wang L, Liu K Abstract Optogenetics is an emerging field, which uses light and molecular genetics to manipulate the activity of live cells by expressing light-sensitive proteins. With the discovery of bacteriorhodopsin, a light-sensitive bacterial protein, in 1971 Oesterhelt and Stoeckenius laid the pavement of optogenetics. However, the cross-integration of different disciplines is a little more than a decade old. The toolbox contains fluorescent sensors and optogenetic actuators which enable visualization of signaling events and manipulation of cellular activities, respectively. Neuropathic pain is a pai...
Conclusion: Cardiac left ventricular and arterial functions are affected in psoriatic children and may be an alarming sign of atherosclerotic heart disease in the long term. Early detection of these changes may be helpful for eliminating other risk factors. PMID: 30997977 [PubMed - as supplied by publisher]
Conclusion: Based on the results obtained, the Turkish version of the PRWHE questionnaire was found to be a valid and reliable scale and it is recommended for the evaluation of patient-based pain and disability level in routine clinical practice. PMID: 30997792 [PubMed - in process]
CONCLUSIONS: The combined therapeutic regimen of HIFU, GnRH-a and LNS-IUS is safe, effective and efficient for curing severe adenomyosis. PMID: 30994010 [PubMed - as supplied by publisher]
CONCLUSION: Providing adequate preoperative information to the patient about regional anesthesia will increase overall satisfaction and will assure the patient feels safe during the perioperative period. CLINICAL TRIAL REGISTRATION NUMBER: NCT03476278. PMID: 30995331 [PubMed - in process]
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