Fast onset of action of glycopyrronium compared with tiotropium in patients with moderate to severe COPD — A randomised, multicentre, crossover trial

Conclusions Glycopyrronium was superior to tiotropium in terms of early bronchodilation. Although both glycopyrronium and tiotropium showed similar improvements in static lung volume parameters, glycopyrronium reduced specific airway resistance faster than tiotropium, which could in part explain the earlier FEV1 response seen with glycopyrronium. Trial registration ClinicalTrials.gov NCT01922271.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research