Neurological Inȷury in Intermediate-Risk Transcatheter Aortic Valve Implantation Interventional Cardiology

ConclusionsObjectively measured subclinical neurological injuries remain a concern in intermediate‐risk patients undergoing TAVI and are likely to manifest with early neurocognitive changes.Clinical Trial RegistrationURL: http://www.anzctr.org.au. Australian &New Zealand Clinical Trials Registry: ACTRN12613000083796.
Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation, Cerebrovascular Disease/Stroke, Cognitive Impairment Original Research Source Type: research

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ConclusionsModerate/severe aortic atherosclerosis was associated with an increased risk of adverse events following SAVR. Epiaortic ultrasound may serve as a useful adjunct for identifying patients who may benefit from strategies to reduce atheroembolic complications during SAVR.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
CONCLUSIONS: Moderate/severe aortic atherosclerosis was associated with an increased risk of adverse events following SAVR. Epiaortic ultrasound may serve as a useful adjunct for identifying patients who may benefit from strategies to reduce atheroembolic complications during SAVR. PMID: 31400333 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Conclusion More extensive myocardial fibrosis is associated with postoperative morbiditiy after mitral valve surgery in patients with rheumatic MS. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: International Journal of Angiology - Category: Cardiology Authors: Tags: Original Article Source Type: research
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD. Commentary on the Developing UK Government Position on Hea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 10 November 2018Source: The Annals of Thoracic SurgeryAuthor(s): Tania Giovannetti, Catherine C. Price, Molly Fanning, Steven Messé, Sarah J. Ratcliffe, Abigail Lyon, Scott E. Kasner, Gregory Seidel, Joseph E. Bavaria, Wilson Y. Szeto, W. Clarke Hargrove, Michael A. Acker, Thomas F. Floyd, DENOVO InvestigatorsAbstractBackgroundAortic valve replacement (AVR) for calcific aortic stenosis is associated with high rates of perioperative stroke and “silent” cerebral infarcts on diffusion-weighted magnetic resonance imaging (MRI), but cognitive outcomes in elderly AVR patients...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ators Abstract BACKGROUND: Aortic valve replacement (AVR) for calcific aortic stenosis is associated with high rates of perioperative stroke and "silent" cerebral infarcts on diffusion-weighted magnetic resonance imaging (MRI), but cognitive outcomes in elderly AVR patients compared with individuals with cardiac disease who do not undergo surgery are uncertain. METHODS: One hundred ninety AVR patients (mean age=76±6y) and 198 non-surgical participants with cardiovascular disease (mean age=74±6y) completed comprehensive cognitive testing at baseline (pre-surgery), and 4-6 weeks and 1-ye...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Authors: Lidén M, Wodecki M, Thunberg P, Rask P Abstract BACKGROUND: Flow measurements using cardiac magnetic resonance imaging (CMRI) enable quantification of the stroke volume, regurgitant volume (RV) and regurgitant fraction (RF) in patients with aortic regurgitation (AR). These variables are used to assess the severity of the valve disease and for the timing of surgery. The aim of the study was to investigate the impact of an increased heart rate on measurement of the RV and RF in patients with AR. METHODS: Among 13 patients with known moderate or severe AR, regurgitant flow measurements, using phase...
Source: Journal of Heart Valve Disease - Category: Cardiology Tags: J Heart Valve Dis Source Type: research
AbstractAbout 60% of patients with paradoxical low-flow, low-gradient (PLF-LG) aortic stenosis (AS) have a severe disease that justifies aortic valve replacement (AVR). The first step in patients with symptomatic PLF AS should be to rule out measurement errors and treat hypertension. The second step is to distinguish pseudo-severe from true severe AS (TSAS). The third step is to select the optimal treatment modality at the right time. Regarding the second step, projected aortic valve area calculated using stress echocardiography is superior to traditional severity criteria (AVA
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Background— In severe asymptomatic primary mitral valve regurgitation without risk factors, surgery strategy is controversial. We sought to clarify whether being symptomatic corresponds to the hemodynamic burden and reduced exercise capacity. A better understanding of this may contribute to optimize timing of surgery. Methods and Results— Subjects with asymptomatic (New York Heart Association functional class I, n=29) or symptomatic (New York Heart Association functional class II and III, n=28) significant primary mitral valve regurgitation (effective regurgitant orifice, ≥0.30 cm2; left ventricular ejectio...
Source: Circulation: Cardiovascular Imaging - Category: Radiology Authors: Tags: Valvular Heart Disease, Echocardiography, Exercise Testing, Magnetic Resonance Imaging (MRI) Source Type: research
Abstract Background -Magnetic resonance imaging (MRI) is an accurate method for the quantitative assessment of organic mitral regurgitation (OMR). The aim of the present study was to compare the discriminative power of MRI quantification and the recommended Doppler-echocardiography (ECHO)-derived integrative approach to identify asymptomatic patients with OMR and adverse outcome. Methods -The study population consisted of 258 asymptomatic patients (63±14 years, 60% males) with preserved left ventricular (LV) ejection fraction (>60%) and chronic moderate and severe OMR (flail 25%, prolapse 75%) defined us...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
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