Impaired vascular function contributes to exercise intolerance in chronic kidney disease

Conclusions
Arterial stiffness contributes to the observed reduced aerobic capacity in predialysis CKD, independent of age, haemoglobin levels and endothelial function and represents a promising therapeutic target for improving exercise capacity in this population. Future work is required to elucidate why higher circulating levels of miR-146a and miR-150 are associated with impaired renal function and increased arterial stiffness.

Source: Nephrology Dialysis Transplantation - December 7, 2016 Category: Urology & Nephrology Authors: Van Craenenbroeck, A. H., Van Craenenbroeck, E. M., Van Ackeren, K., Hoymans, V. Y., Verpooten, G. A., Vrints, C. J., Couttenye, M. M. Tags: Chronic Kidney Disease Source Type: research