A Dexamethasone-regulated Gene Signature Is Prognostic for Poor Survival in Glioblastoma Patients

Conclusions: Dexamethasone exposure induces a genetic program and CEBPB expression in GSCs that adversely affects key cellular functions and response to therapeutics. High risk scores associated with these genes have negative prognostic value in patients. Our findings further suggest camptothecin as a potential neutralizer of adverse dexamethasone-mediated effects.
Source: Journal of Neurosurgical Anesthesiology - Category: Anesthesiology Tags: Laboratory Investigations Source Type: research