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In Depth Worries, confusion after cancer trial deaths

An experimental cancer therapy is facing its biggest setback yet, after an unexpected complication killed seven people, five of them in a single clinical trial. The company, Seattle, Washington–based Juno Therapeutics, has its most troubled trial on hold and is racing to figure out why patients suffered fatal brain swelling, called cerebral edema. Researchers elsewhere are grappling with possible ramifications for the breakthrough treatment, in which a patient's T cells are genetically engineered to fight cancer. Called chimeric antigen receptor–T therapy, it goes up for drug approval next year. Doctors speculate that the cerebral edema could be due to the specific product tested and the trial's patient population, rather than the overall strategy itself. But they're mostly in the dark, and hope that additional research, including new animal models, could help explain what happened and why. Author: Jennifer Couzin-Frankel
Source: ScienceNOW - Category: Science Authors: Tags: Cancer Immunotherapy Source Type: news

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Authors: Wang R, Zhou T, Liu W, Zuo L Abstract Cancer cells subjected to ionizing radiation may release signals which can influence nearby non-irradiated cells, termed bystander effects. The transmission of bystander effects among cancer cells involves the activation of inflammatory cytokines, death ligands, and reactive oxygen/nitrogen species. In addition to bystander effects, two other forms of non-target effects (NTEs) have been identified in radiotherapy, as one is called cohort effects and the other is called abscopal effects. Cohort effects represent the phenomenon where irradiated cells can produce signals ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Cancer Therapy and Prevention Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Keynote Lectures Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Of Interest Source Type: blogs
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