Person of the Year 2016 Runner-Up: The CRISPR Pioneers
[time-ad size=”large”] Table of ContentsPerson of the Year THE CHOICE DONALD TRUMP The Short List HILLARY CLINTON THE HACKERS RECEP TAYYIP ERDOGAN THE CRISPR PIONEERS BEYONCÉ Plus EUROPE’S POPULIST REVOLT ARE PRESIDENTS ALWAYS POY? 90 YEARS OF POY BY ALICE PARK Dr. Carl June’s lab at the University of Pennsylvania looks like any other biology research hub. There are tidy rows of black-topped workbenches flanked by shelves bearing boxes of pipettes and test tubes. There’s ad hoc signage marking the different workstations. And there are postdocs buzzing around, calibrating scales, checking incubators and smearing solutions and samples onto small glass slides. Appearances aside, what June is attempting to do here, on the eighth floor of the glass-encased Smilow Center for Translational Research in Philadelphia, is anything but ordinary. He’s built a career trying to improve the odds for people with intractable end-stage disease, and now, in the university’s brand-new cell-processing lab, he’s preparing to launch his most ambitious study yet: he’s going to try to treat 18 people with stubborn cancers, and he’s going to do it using CRISPR, the most controversial new tool in medicine. Developed just four short years ago by two groups—Jennifer Doudna, a molecular and cell biologist at the University of California, Berkeley, together with Emmanuelle Charpentier, now at the Max Planck Institu...
Minneapolis is the third-fittest city in the nation, while St. Paul is ranked No. 12. That's according to the 13th annual fitness index study released Tuesday by the American College of Sports Medicine and the Anthem Foundation, which ranked Minneapolis behind Arlington, Va. and Seattle, Wa. out of the 100 largest cities in the country. Scores were compiled via surveys of residen ts across 33 areas like health behaviors (exercise and nutrition habits), prevalence of chronic diseases (obesity,…
Publication date: Available online 12 July 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): A. Biggerstaff, B. Kivell, J.L. Smith, Md Y. Mian, L.K. Golani, F. Rashid, D. Sharmin, D.E. Knutson, R. Cerne, J.M. Cook, J.M. Witkin
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ05989J, PaperK S Sharma, A. K. Dubey, Arunkumar S, Koijam, Chandan Kumar, Anand Ballal, Sudip Mukherjee, Prasad P Phadnis, R K Vatsa Abstract Water soluble Pt(IV) prodrug of cisplatin was synthesized by oxidation of cisplatin followed by treatment with succinic anhydride to achieve easily reducible ester linkage at axial positions which was... The content of this RSS Feed (c) The Royal Society of Chemistry
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ02844D, PaperMuhammad Khattab, Ahmed A. Al-Karmalawy Preclinical and clinical studies on Mebendazole revealed its potential as anticancer agent. We therefore aimed to investigate its binding interactions with one of the most important cancer targets (Tubulin protein)... The content of this RSS Feed (c) The Royal Society of Chemistry
New J. Chem., 2020, Advance Article DOI: 10.1039/D0NJ02175J, PaperPhanumas Yomthiangthae, Takeshi Kondo, Orawon Chailapakul, Weena Siangproh A simple and modification-free SPCE demonstrated high efficiency for the simultaneous detection of VB2, VB6, and VC in various practical applications. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Lab Chip, 2020, Accepted Manuscript DOI: 10.1039/D0LC00268B, PaperJianhua Qin, Yujuan Zhu, Hui Wang, Fangchao Yin, Yaqiong Guo, Fei Li, Dong Gao Amnion serves to create a protective environment for growing fetus and the study of amniotic development will greatly facilitate our understanding of normal and diseased pregnancy. However, it remains poorly... The content of this RSS Feed (c) The Royal Society of Chemistry
Mice that experienced heart attacks underwent a large-scale shift in their immune systems that allowed cancer to flourish, perhaps explaining the observation in patients.
Conclusion: In this cohort of patients with esophageal cancer admitted to intensive care units with acute illness, the in-hospital mortality rate was very high. The requirement for invasive mechanical ventilation and metastatic disease were independent prognostic factors and should be considered in discussions about the short-term outcomes of these patients.
Loss of chromosome Y (LOY) is a mosaic aneuploidy that can be detected mainly in blood samples of male individuals. Usually, LOY occurrence increases with chronological age in healthy men. Moreover, recently LOY has been reported in association with several diseases, such as cancer, where its frequency is even higher. The Y chromosome is one of the shortest chromosomes of the human karyotype, and it is crucial for correct male development. This chromosome has functions beyond the male reproductive system, and loss of its genes or even LOY can have consequences for the male body that are yet to be elucidated. Analyses of th...
ConclusionsAortoiliac calcification may be considered a risk factor for grade C AL after rectal cancer surgery.
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