The appropriate dose and cost of iron replacement therapy in patients with IBD

We read with great interest the article by Lee et al,1 who performed an open-label clinical trial to compare the effects of per os (PO) versus intravenous iron replacement therapy (IRT) for iron deficiency in patients with IBD. They concluded that IRT in patients with iron deficiency or anaemia induced significant shifts in bacterial community structure and metabolite landscape in faeces, and PO iron therapy affected the presence of specific molecular bacterial species. These are impressive findings that raise two important issues. First, Lee et al1 enrolled participants with Crohn’s disease (n=31), UC (n=22) and non-IBD control anaemic subjects (n=19) for IRT intervention 3 months PO iron sulfate or intravenous iron sucrose. PO participants took one 300 mg iron sulfate tablet twice each day. IV patients received three or four separate iron sucrose (300 mg) infusions if iron deficient only or with anaemia, respectively. This is a very...
Source: Gut - Category: Gastroenterology Authors: Tags: PostScript Source Type: research

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Conclusions: Due to short follow-up time in small studies, with selection bias due to exclusion of former or prevalent malignancy in an older population, no conclusions can be drawn concerning the true association between MC and malignancy. Rheumatic diseases seem to be associated with MC. PMID: 32182146 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Hairy, scary, funny looking or pretty cool. The beasts in the Harry Potter universe are quite the diverse bunch with unique abilities and qualities. Just like new digital health tech targeted to fight autoimmune diseases or for the main part: their symptoms. Source: Warner Bros. Framestore The common ground for completely different illnesses like type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis is an immune system disfunction. Immune cells and mechanisms target the body’s own cells and structures, deconstructing it bit by bit and inducing inflammation. An estim...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Biotechnology Future of Medicine chatbot diabetes digital health sleep optimization chronic pain chronic illness skin coronavirus autoimmune disease Source Type: blogs
Abstract BACKGROUND: To examine differences in comorbidities and surgical management based on socioeconomics in hospitalized children with Crohn's disease (CD). METHODS: Using the Kids' Inpatient Database for 2006-2012, we identified patients (
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Authors: Yue Ying C, Jun S, Yu Fan W, Hua RZ Abstract Introduction: Anemia is a common extraintestinal complication of Crohn's disease (CD) mainly caused by iron deficiency and, affects the quality of life of CD patients. In recent years, the etiology and pathology of iron-deficiency anemia (IDA) and anemia of chronic diseases have been elucidated. However, common biochemical parameters of iron status for the assessment of patients with anemia and CD are insufficient. Thus, novel iron indices are required for accurate assessment in CD patients with IDA. Oral iron supplementation as IDA treatment is common and assoc...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Abstract BACKGROUND: Incidence and severity variations of inflammatory bowel disease (IBD) have been reported from Western populations between continents and regions of the same countries. However, no data were available from other countries. AIM: To investigate the regional differences in the IBD profiles of pediatric patients from the Kingdom of Saudi Arabia. METHODS: Data from a national multicenter IBD study were used. The incidence, time trend, and clinical presentation of Crohn's disease (CD) and ulcerative colitis (UC) in the Central region (CR), Western region (WR), and Eastern region (ER) were a...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
CONCLUSION: History of cigarette smoking, anemia, underweight and CKD are possible risk factors for CD in Asians aged> 40 years. PMID: 32063689 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Anemia is a common systemic complication of inflammatory bowel disease (IBD), with reported prevalence up to 74%. Anemia is associated with worse disease outcome and quality of life. The Crohn ’s and Colitis Foundation recently published an initiative quantifying the healthcare cost of IBD patients. They found that the presence of anemia was associated with high resource utilization, particularly hospitalization. The purpose of this study was to determine how anemia severity impacts hea lthcare utilization and if treatment of anemia reduces healthcare utilization.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Disease Complications Source Type: research
ConclusionsScurvy is caused by vitamin C deficiency. Cutaneous bleeding, mucosal bleeding, and anemia represent typical manifestations of the disease. These symptoms are directly connected to ascorbic acid involvement in collagen biosynthesis. Some radiographic findings can be useful for the diagnosis. Treatment aims to normalize serum levels of vitamin C in order to counteract the deprivation symptoms. The present case report demonstrates that scurvy may sporadically occur in pediatric patients, even in individuals with no predisposing medical conditions and/or potential risk factors.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates its biological roles through a hexameric complex composed of IL-6 itself, its receptor IL-6R, and glycoprotein 130 (IL-6/IL-6R/gp130). This complex, in turn, activates different signaling mechanisms (classical and trans-signaling) to execute various biochemical functions. The trans-signaling mechanism activates various pathological routes, like JAK/STAT3, Ras/MAPK, PI3K-PKB/Akt, and regulation of CD4+ T cells and VEGF levels, which...
Source: Bioorganic and Medicinal Chemistry - Category: Chemistry Authors: Tags: Bioorg Med Chem Source Type: research
CONCLUSIONS: Specific signs and symptoms, chronic conditions, a greater comorbidity burden, and specific pharmacological treatments registered in primary care databases represent relevant predictors and correlates of incident IDA in older people in Europe. General practitioners might employ this information to obtain early diagnosis of IDA in community-dwelling older adults. PMID: 31893385 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Tags: Aging Clin Exp Res Source Type: research
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