Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma

Conclusions
SSAs containing dysplasia/carcinoma are predominantly small (<10 mm) and proximal. The mismatch repair status separates these lesions into distinct clinicopathological subgroups, although WNT activation and p16 silencing are common to both. Cases with dysplasia occur at a similar age to cases with carcinoma. This, together with the rarity of these ‘caught in the act’ lesions, suggests a rapid transition to malignancy following a long dwell time as an SSA without dysplasia.

Source: Gut - December 6, 2016 Category: Gastroenterology Authors: Bettington, M., Walker, N., Rosty, C., Brown, I., Clouston, A., McKeone, D., Pearson, S.-A., Leggett, B., Whitehall, V. Tags: Colon cancer Source Type: research