hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation

Conclusions
The hTERT/MDM2–FOXO3a–ITGB1 pathway markedly contributes to hTERT-promoted gastric cancer invasion, suggesting that this pathway might be a novel target for the prevention and treatment of gastric cancer metastasis.

Source: Gut - December 6, 2016 Category: Gastroenterology Authors: Hu, C., Ni, Z., Li, B.-s., Yong, X., Yang, X., Zhang, J.-w., Zhang, D., Qin, Y., Jie, M.-m., Dong, H., Li, S., He, F., Yang, S.-m. Tags: Pancreatic cancer Stomach Source Type: research