Ultrasound Promoted Synthesis and Anticoagulant Activity of 2-amino-4H-chromen-4-ylphosphonates.

CONCLUSION: The findings from this study highlight that ultrasonication of the one pot three compo-nent reaction of salicylaldehyde derivatives, malononitrile and dialkyl phosphite with piperazine as a catalyst for the synthesis of 2-amino-4H-chromen-4-ylphosphonates is the best method. In vitro co-agulant assay in terms of prothrombin time (PT) revealed that 4j, 4h and 4g possess promising antico-agulant properties. Other compounds (4a-l) were also found to have significant anticoagulant effect when compared with the heparin as positive control. Thus, these compounds qualify for further clinical studies to be used as the blood anticoagulants. PMID: 27917720 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research