18 Diseases The World Has Turned Its Back On

This article is part HuffPost’s Project Zero campaign, a yearlong series on neglected tropical diseases and efforts to eliminate them. More than 1 billion people on the planet suffer from illnesses that the world pays little attention to. Neglected tropical diseases are a group of at least 18 diseases that primarily affect people living in poverty in tropical regions of the world and are virtually unknown elsewhere, according to the World Health Organization. These are diseases like river blindness, which has infected 18 million people worldwide and caused blindness in 270,000 people; or elephantiasis, a leading cause of disability worldwide, which affects over 120 million people and can cause severe swelling of the body parts, usually the legs or the scrotum. While only some of these illnesses can be fatal, many of them can cause lifelong disabilities or disfigurement. And even though many neglected tropical diseases are preventable and treatable, getting proper medical care to the people who are most vulnerable can be challenging, as the diseases primarily affect people in high-poverty communities with limited access to health services. “Because they are a threat only in impoverished settings, they have low visibility in the rest of the world,” WHO Director-General Margaret Chan says in a 2010 report. “While the scale of the need for treatment is huge, the poverty of those affected limits their access to interv...
Source: Science - The Huffington Post - Category: Science Source Type: news

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In this study, we found that TLR1/TLR2 expression predicted favorable prognosis of lung cancer patients. In the related mice tumor model, TLR1/TLR2 activation by synthetic bacterial lipoprotein (BLP), a TLR1/2 agonist, greatly inhibited tumor growth and selectively decreased monocytic MDSCs (M-MDSCs). Furthermore, BLP treatment redirected M-MDSC differentiation towards M1 macrophage through JNK pathway, and thus blocked the suppressive activity of M-MDSCs in a TLR2-dependent manner. Therefore, our data demonstrated that TLR2 could be a promising biomarker and a potential immunotherapeutic target for lung cancer.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 15 June 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Yang Xiong, Ying Wang, Karthik TiruthaniAbstractColorectal cancer (CRC) is predicted to be the 2nd leading cause of cancer-related death in United States in 2019. Immunotherapies such as checkpoint inhibitors have proven efficacy in patients with high level of microsatellite instability and refractory to routine chemotherapy. Despite this, immunotherapy-based treatment is seriously limited by cancer immunogenicity which are evolved to evade immune surveillance in many circumstances. Efforts are made by resear...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: Available online 15 June 2019Source: Nano TodayAuthor(s): Weijing Yang, Zijian Zhou, Joseph Lau, Shuo Hu, Xiaoyuan ChenAbstractImmunotherapy (e.g., checkpoint blockade, adoptive T cell therapy, cancer vaccine) has emerged as one of the most important treatment modalities for cancer in the past two decades. While these approaches are promising, the response rates observed in clinical trials are less than 30% due to tumor heterogeneity and complexity of the tumor microenvironment. Smart nanosystems have the potential to address some of the limitations associated with immunotherapy. Herein, we review applica...
Source: Nano Today - Category: Nanotechnology Source Type: research
Publication date: Available online 14 June 2019Source: Neuroscience LettersAuthor(s): Junjie Zhao, Ming ZhangAbstractTraumatic brain injury affects a number of individuals per year and is a major cause of worldwide death and disability. Yet, its pathophysiological mechanism remains unclear. It is well-known that glial cells, including microglia and astrocytes, are activated and involved in tissue damage and repair in the peri-lesion regions after traumatic brain injury; however, global glial responses are rarely reported. The purpose of this study was to investigate the global activation of microglia and astrocytes 1 day a...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
We present a two parts review discussing the unique features of the elderly patient harboring an intracranial neoplasm. In this Part-I, we review the management of benign meningioma in the elderly population.Meningioma is the second most common primary brain tumor. The risk of developing meningioma increases dramatically after 65 years of age. Predicting a specific meningioma’s growth pattern and clinical behavior is impossible. Clinicians must choose between GTR with associated morbidity/ mortality, SRS or a combined AHS approach, since progression rates after STR are high. Several scoring systems attempt to offer...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
This study included 65 patients with lumbar spondylolisthesis, who underwent either open transpedicular screw fixation (OTPSF) with posterior lumbar interbody fusion (PLIF) (OTPSF group, n = 33) or PPSF with reduction system (PPSFr group, n = 32) after PLIF. The slippage degree (SD); the intervertebral disc height (IDH); lumbar lordosis (LL); and segmental angle (SA) were measured on the follow-up simple lateral radiographs. For pain and functional assessment in patients, visual analogue scale (VAS) scores for low back pain and leg pain, and Oswestry Disability Index (ODI) scores were measured. SA (P 
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: August 2019Source: Clinica Chimica Acta, Volume 495Author(s): Yujia He, Abidali Mohamedali, Canhua Huang, Mark S. Baker, Edouard C. NiceAbstractOncoproteomics is the systematic study of cancer samples using omics technologies to detect changes implicated in tumorigenesis. Recent progress in oncoproteomics is already opening new avenues for the identification of novel biomarkers for early clinical stage cancer detection, targeted molecular therapies, disease monitoring, and drug development. Such information will lead to new understandings of cancer biology and impact dramatically on the future care of can...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Abstract Base excision DNA repair (BER) is a vitally important pathway that protects the cell genome from many kinds of DNA damage, including oxidation, deamination, and hydrolysis. It involves several tightly coordinated steps, starting from damaged base excision and followed by nicking one DNA strand, incorporating an undamaged nucleotide, and DNA ligation. Deficiencies in BER are often embryonic lethal or cause morbid diseases such as cancer, neurodegeneration, or severe immune pathologies. Starting from the early 1980s, when the first mammalian cell lines lacking BER were produced by spontaneous mutagenesis, s...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
This study demonstrates that NSCLC cells resistant to gefitinib (GR cells) displayed a significantly higher microsomal prostaglandin E synthase-1 (mPGES-1) expression and activity than parental cells. Overexpression of mPGES-1/prostaglandin E-2 (PGE-2) signaling in GR cells was associated with acquisition of mesenchymal and stem-like cell properties, nuclear EGFR translocation and tolerance to cisplatin. mPGES-1 inhibition reduced mesenchymal and stem-like properties, and nuclear EGFR translocation in GR cells. Consistently, inhibition of mPGES-1 activity enhanced sensitivity to cisplatin and responsiveness to gefitinib in...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Conclusion: This study showed that periodontal diseases were associated with increased risk of several cancers. Besides other wellknown benefits for health, the provision of oral/dental health should be considered and employed as a cancer prevention measure. PMID: 31195790 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
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