Woman becomes mother to own GRANDCHILD by having surrogate baby for daughter

Jessica Bradford, from Gwent, Wales, was left infertile from chemotherapy and had her eggs frozen three years ago. In May, one of her embryos was inserted into Julie's womb.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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We report a case of a 42-year-old woman with a history of bilateral ductal carcinoma of the breast who underwent radical mastectomy with chemotherapy and radiotherapy was anxious to conceive. In vitro fertilization was performed with donor oocyte; the patient became pregnant and delivered a full term baby with no congenital anomalies. As very few have a background for providing guidance and treatment in this setting, this report highlights the possibility of improving the quality of reproductive life of young survivors by various assisted reproductive techniques, the importance of fertility preservation and a multidisciplinary team approach.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Abstract Cancer patients' quality of life is greatly dependent on the efficacy of treatments and their associated side effects, which can significantly reduce the overall quality of life. Although the effectiveness of cancer treatments has improved over time, adverse effects persist with each treatment. Some side effects, such as paclitaxel-induced peripheral neuropathy, can be dose limiting, thus further reducing the potential of paclitaxel chemotherapy treatment. Premature ovarian failure in young female patients due to radiation and chemotherapy therapy can have devastating infertility consequences. In rec...
Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research
Purpose of review Although platinum-based chemotherapy (CHT) remains the cornerstone of clinical stage I testicular germ cell tumor (GCT) treatment, its long-term toxicity and complications in cancer survivors are unclear. Recent findings Cardiovascular disease and secondary malignancies represent the most life-threatening long-term complications and typically occur 10 years after treatment. Other potential intermediate deleterious effects include pulmonary toxicity, ototoxicity, neurotoxicity, hypogonadism and infertility. The incidence and time to onset vary according to patients’ genetic susceptibility, CHT r...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: TESTICULAR CANCER: Edited by Aditya Bagrodia and Peter Albers Source Type: research
Publication date: Available online 21 July 2018Source: Small Ruminant ResearchAuthor(s): Jeanette Olejnik, Natalka Suchowerska, Muren Herrid, Michael Jackson, Geoff Hinch, Jonathan HillAbstractMany alternatives to surgical castration have been explored to induce short or long term infertility in male animals. Comparatively few have been carefully evaluated in very young production animals. A comparison of four treatments known to deplete testicular cells in rodents (heating, cooling, chemotherapy, radiation) was undertaken using ram lambs.Neither testicular cooling (0 °C) nor heating (45 °C) affected ...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Authors: Zarandi NP, Galdon G, Kogan S, Atala A, Sadri-Ardekani H Abstract While the survival rate of children with cancer is increasing, preserving fertility for prepubertal boys is still a challenge. Although intracytoplasmic sperm injection (ICSI) using frozen sperms has revolutionized infertility treatment, it is not applicable for the patients who undergo chemotherapy before puberty since spermatogenesis has not begun. Therefore, preserving spermatogonial stem cells (SSCs) as an experimental option can be provided to prepubertal patients at a risk of damage or loss of their SSCs due to cancer treatments and de...
Source: Stem Cells and Cloning: Advances and Applications - Category: Stem Cells Tags: Stem Cells Cloning Source Type: research
CONCLUSION: Despite a more frequent presentation with advanced disease, colorectal cancer has a similar prognosis in pregnancy when compared with the general population. Diagnostic interventions and treatment should not be delayed due to the pregnancy but a balance between maternal and foetal wellbeing must always be kept in mind. PMID: 30010511 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
Publication date: Available online 28 June 2018Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Wanyuan Cui, Kelly-Anne PhillipsAbstractGlobally, breast cancer is the most common female reproductive cancer. Although not part of initial curative-intent treatment in women with other reproductive cancers, alkylating chemotherapy is often used to treat women with curable breast cancer. Chemotherapy-associated ovarian failure (COF) is a potential consequence of this treatment, and can cause infertility and increase the risk of cognitive impairment, cardiovascular disease and fractures from redu...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
Publication date: April 2018Source: Best Practice &Research Clinical Obstetrics &Gynaecology, Volume 48Author(s): Gabriela N. Algarroba, Joseph S. Sanfilippo, Hanna Valli-PulaskiAbstractThe 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all patie...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
Publication date: Available online 28 June 2018Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Wanyuan Cui, Kelly-Anne PhillipsAbstractGlobally, breast cancer is the most common female reproductive cancer. Although not part of initial curative-intent treatment in women with other reproductive cancers, alkylating chemotherapy is often used to treat women with curable breast cancer. Chemotherapy-associated ovarian failure (COF) is a potential consequence of this treatment, and can cause infertility and increase the risk of cognitive impairment, cardiovascular disease and fractures from redu...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
Publication date: April 2018Source: Best Practice &Research Clinical Obstetrics &Gynaecology, Volume 48Author(s): Gabriela N. Algarroba, Joseph S. Sanfilippo, Hanna Valli-PulaskiAbstractThe 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all patie...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
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