Long Noncoding RNA Meg3 Controls Endothelial Cell Aging and Function Implications for Regenerative Angiogenesis

The majority of transcribed ribonucleic acid (RNA) does not encode proteins, but it may function as regulatory RNA. Long noncoding RNA (lncRNA) have been described as playing an important role in  many biological processes, including epigenetic regulation of gene expression. To determine the expression and functional role of lncRNA in endothelial cells, we recently performed RNA deep sequencing of human umbilical venous endothelial cells (HUVECs)(1). Aging is known to induce endothelial dysfunction(2), and we hypothesized that lncRNA contribute to aging-associated decline in endothelial function.

Source: Journal of the American College of Cardiology - December 5, 2016 Category: Cardiology Source Type: research