Alpha blockers more effective for large kidney stones

For the two-thirds of kidney stone patients who need more than just extra hydration to pass their stones, physicians are eager to find non-surgical ways to help. Now, a new review of the medical literature suggests alpha blockers may be useful in some cases.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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We thank Sheng-Wen Niu and colleagues1 for highlighting their intriguing data on the association between pioglitazone use and incident nephrolithiasis in patients with type 2 diabetes in the Taiwanese National Health Insurance Research Database. In their population-based retrospective analysis, pioglitazone users experienced a 26% reduction in kidney stone incidence compared with matched diabetic nonpioglitazone users, and greater risk reduction was observed with higher cumulative pioglitazone exposure.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
Maalouf et  al.1 investigated the urinary biochemical effect of pioglitazone in patients with idiopathic uric acid nephrolithiasis. They showed that pioglitazone not only improved the metabolic syndrome, but also increased urine pH by reducing the acid load to the kidney, raising ammoniagenesis and ammonium e xcretion. However, the study size was small and whether pioglitazone will affect the incidence of nephrolithiasis in patients with the metabolic syndrome or diabetes or both is unknown. The interesting observation by Maalouf et al.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
AbstractThere is controversy regarding the predicting value of preoperative urine culture for post-percutaneous nephrolithotripsy (PCNL) infection. The purpose of our study was to re-evaluate the importance of preoperative urine culture for developing post-PCNL systemic inflammatory response syndrome (SIRS) in China. A total of 303 patients undergone PCNL from March 2012 to January 2018 were recruited. Urine tests, urine cultures and the perioperative data were prospectively recorded and analyzed. 95 patients (31.4%) were identified with positive preoperative urine cultures. Female patients had significantly higher rate of...
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
If you’ve been diagnosed with kidney stones (urolithiasis), you may have several options for treatment. These include medical therapy, extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotripsy (PCNL), and ureteroscopy. A brief anatomy of the urinary tract The urinary tract includes kidneys (two organs that filter waste and extra water from the blood) ureters (two tubes bringing urine from each kidney to the bladder) bladder (organ that collects urine) urethra (a single tube through which urine in the bladder passes out of the body). The evaluation for kidney stones If your symptoms suggest kidney...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Kidney and urinary tract Men's Health Women's Health Source Type: blogs
AbstractObjectivesWe aimed to evaluate the role of nephrin and podocalyxin in determining the intervals between shock wave lithotripsy (SWL) sessions and how soon the kidney damage was recovered.MethodsThis work was a prospective study that included 30 patients with unilateral kidney stones. The patients ’ midflow urine samples were collected before SWL and 1 h, 1 day and 1 week after the procedure. Nephrin and podocalyxin levels in the urine samples were measured by the enzyme-linked immunosorbent assay method.ResultsAmong the 30 patients who underwent SWL, 19 were males and 11 were females. The mean ...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
AbstractStandard of care for large or complex renal stones is percutaneous nephrolithotomy. Robotic pyelolithotomy, however, may be a feasible alternative, but limited data exist on its outcomes and complications. Our study objective was to describe the outcomes and peri-operative complications of robotic pyelolithotomy for complex renal calculi. We performed a retrospective analysis of robotic pyelolithotomy at our tertiary academic institution from 2015 to 2018. Demographics, stone clearance rates, complications, estimated blood loss, operative time, and length of stay were reported. 15 patients were included with a medi...
Source: Journal of Robotic Surgery - Category: Surgery Source Type: research
Conditions:   Urolithiasis;   Calyx; Calculus Interventions:   Dietary Supplement: Potassium and magnesium citrate;   Dietary Supplement: Placebo Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: Critical Reviews in Food Science and Nutrition - Category: Nutrition Authors: Source Type: research
When the National Institutes of Health convened the first workshop devoted to the diagnosis and management of primary hyperparathyroidism (pHPT) in 1990, astute clinicians had already appreciated that the classic presentation of this disorder, established decades before as symptomatic and progressive, was no longer the typical face of the disease. Primary hyperparathyroidism was being diagnosed with increasing frequency in asymptomatic patients and those for whom reduced bone mass was the main clinical finding. Guidelines published in 1991 from that first National Institutes of Health conference outlined the diagnostic cri...
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
Publication date: Available online 13 July 2019Source: European UrologyAuthor(s): James F. Donaldson, Yasir Ruhayel, Andreas Skolarikos, Steven MacLennan, Yuhong Yuan, Robert Shepherd, Kay Thomas, Christian Seitz, Aleš Petrik, Christian Türk, Andreas NeisiusAbstractContextBladder stones (BS) constitute 5% of urinary stones. Currently, there is no systematic review of their treatment.ObjectiveTo assess the efficacy (primary outcome: stone-free rate [SFR]) and morbidity of BS treatments.Evidence acquisitionThis systematic review was conducted in accordance with the European Association of Urology Guidelines Offic...
Source: European Urology - Category: Urology & Nephrology Source Type: research
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