Pharmacokinetics of Imipenem/Cilastatin Burn Intensive Care Unit Patients Undergoing High ‐Dose Continuous Venovenous Hemofiltration

ConclusionEfficient removal of I/C by high‐dose CVVH, a high overall clearance, and a high volume of distribution in burn intensive care unit patients undergoing this CRRT method warrant aggressive dosing to treat serious infections effectively depending on the infection site and/or pathogen.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 3, 2016 Category: Drugs & Pharmacology Authors: Bradley A. Boucher, Joanna Q. Hudson, David M. Hill, Joseph M. Swanson, G. Christopher Wood, S. Casey Laizure, Angela Arnold ‐Ross, Zhe‐Yi Hu, William L. Hickerson Tags: Original Research Article Source Type: research