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Equatorial Guinea: Ebola - Facing Down Fear to Save Lives in Guinea

[IFRC]In Conakry, the capital of Guinea, everyone is frightened of the Ebola virus disease. It is the first time one of the most lethal viruses in the world has been detected in the country and stories are surfacing of people panicking, such as the time when passengers in a public transport vehicle abandoned the bus, in the middle of a traffic jam, when a pregnant woman inside, vomited.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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(NIH/National Institute of Allergy and Infectious Diseases) Ebola virus can infect reproductive organs of male and female macaques, according to a new study, suggesting humans could be similarly infected. Prior studies have revealed sexual transmission of Ebola virus, and viral RNA persisting in semen following recovery. While little is known about viral persistence in female reproductive tissues, pregnant women with Ebola virus disease have a maternal death rate of more than 80 percent and a fetal death rate of nearly 100 percent.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract During gestation, the immune response of the placenta to viruses and other pathogens plays an important role in determining a pregnant woman's vulnerability toward infectious diseases. Located at the maternal- fetal interface, trophoblast cells serve to minimize the spread of viruses between the host and developing fetus through an intricate system of innate antiviral immune signaling. Adverse pregnancy outcomes, ranging from learning disabilities to preterm birth and fetal death, are all documented results of a viral breach in the placental barrier. Viral infections during pregnancy can also be spread th...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
The 2014 to 2016 Ebola outbreak, primarily based in 3 West African countries, had far-reaching global effects. Importantly, the crisis highlighted large gaps in reproductive health services in affected countries and inadequate health care system preparedness for obstetrical patients in the setting of highly contagious infectious diseases. We aim to review Ebola virus effects with a focus on the obstetrical implications in the context of this recent Ebola outbreak, discuss the lessons learned following this outbreak and propose current measures specific to obstetrics that should be considered in preparation for the next con...
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Perinatal Viral Infections: Considering Achievements, Opportunities, and Paradoxes in Management Source Type: research
(Am J Obstet Gynecol. 2017;216(1):34.e1–34.e5) The Zika virus epidemic raised many questions in relation to birth defects in infants born to mothers infected with Zika. This included whether the risk of adverse outcomes could be reduced after infection. During both the 2009 H1N1 pandemic and the 2014 to 2015 Ebola epidemic, there were missed opportunities to involve pregnant women in research to better understand poor neonatal outcomes or the effects of antiviral medications on pregnant women and neonates.
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Short Takes Source Type: research
November 10, 2017In the global health community, we often talk about reaching the “last mile”—generally those who live in the hardest-to-reach places of the world, farthest from the health services they need. But from the point of view of those families, the last mile is in fact the first mile.The global information and communications technology community seems to understand this more than we do in health. Studies  such as this look directly at first-mile issues—that is, “how connectivity looks, feels, and behaves from the subscriber's perspective. ” And researchers have done&n...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Source Type: news
Introduction The Ebola virus disease (EVD) outbreak started in Guinea in 20131,2, and as of June 10, 2016, 28,616 cases had been registered, with 11,310 deaths32. After the end of the original outbreak, in the three most affected countries in 20152, specifically, in Liberia in May, Sierra Leone in November, and Guinea in December, different flare-ups were reported. The biggest flare-up was in Guinea, which occurred from February 274 to June 1, 2016, with 10 reported cases and seven deaths3, while the smallest one was in Sierra Leone, from January 14 to March 17, 2016, with two reported cases and one death5. Flare-ups may ...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
[Observer] A woman who delivered twins during the height of the Ebola Crisis is appealing to humanitarians and organizations to come to her aid so she can adequately support the children.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
This study shows that a herpes viral infection of FMs sensitizes the tissue to low levels of bacterial LPS, giving rise to an exaggerated IL-1β response. Using an ex vivo human FM explant system and an in vivo mouse model of pregnancy, we report that the mechanism by which this aggravated inflammation arises is through the inhibition of the TAM receptor, MERTK, and activation of the inflammasome. The TAM receptor ligand, growth arrest specific 6, re-establishes the normal FM response to LPS by restoring and augmenting TAM receptor and ligand expression, as well as by preventing the exacerbated IL-1β processing an...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: midwives who worked in Ebola centres in Sierra Leone have a wide range of experiences in caring for pregnant women affected by Ebola. Their views should therefore be sought and considered when new guidelines are being developed on how best to provide care for pregnant women during an outbreak of Ebola virus disease, or any comparable infectious disease. Balanced information, sufficient training, adequate equipment and access to support by colleagues and peers would assist the midwives in coping with the challenges they face. PMID: 28915377 [PubMed - as supplied by publisher]
Source: Midwifery - Category: Midwifery Authors: Tags: Midwifery Source Type: research
ConclusionThis study showed that fear of contracting ZIKV is not a major deterrent for travelling to high-risk areas. Pregnant women are appropriately concerned about the risk of ZIKV. Studies modelling the further spread of ZIKV need to account for these results.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
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