Individualized Antibiotic Therapy in Patients with Ventilator-Associated Pneumonia.
Individualized Antibiotic Therapy in Patients with Ventilator-Associated Pneumonia.
J Med Microbiol. 2016 Dec 01;:
Authors: Yilmaz G, Saylan S, Aksoy F, Koksal I
Abstract
The optimal duration of treatment of ventilator-associated pneumonia (VAP) is still the subject of debate. While 1-week treatment has been reported as possibly sufficient, patients generally receive antibiotic therapy for 10-14 days. The purpose of our study was to investigate whether length of treatment in patients with VAP can be reduced with an individualized therapeutic strategy. The study was performed prospectively with patients diagnosed with VAP in our hospital's intensive care units between 1 January and 31 December, 2015. Duration of antibiotic therapy was determined with 5-day clinical evaluation according to previously established criteria. Patients were divided into two groups depending on length of treatment, short (7-10 days) and long treatment (>10 days). Nineteen patients received 7-10 day antibiotic therapy, and 30 received >10-day antibiotic therapy. Demographic and clinical characteristics, Glasgow Coma Score (GCS), CPIS and the PaO2/FiO2 ratio at time of diagnosis of VAP were statistically similar between the two groups(p>0.05). A second VAP attack occurred post-treatment in three patients receiving short-term treatment and in four receiving long-term treatment(p=0.561).Numbers of antibiotic-free days were 15.6±6.2 in the short-term tr...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Yilmaz G, Saylan S, Aksoy F, Koksal I Tags: J Med Microbiol Source Type: research
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