Are there raccoons in your garden?
Imagine that you are planning to plant a garden in springtime. You clear the soil of grass and weeds, sift out the rocks, fold in some manure or composted material to enrich the soil. You then plant seeds for squash, peppers, maybe some heirloom carrots. You water the garden and then wait for the seeds to sprout, hoping for a glorious bounty of veggies in a couple of months. But you forgot that there are raccoons, rabbits, and deer in the neighborhood, creatures eager to eat your work. Sprouts come up, leaves, then young vegetables—only to disappear overnight after a raccoon or rabbit feast. So it goes with the garden you call bowel flora: you prepare the “soil,” plant the seeds (probiotics and fermented foods), then “water” and “fertilize” the garden (prebiotic fibers). You don’t have raccoons or rabbits in your intestinal tract, of course, but you have many other factors that, in effect, wreak havoc on your intestinal garden of microorganisms that protect you and your health. The factors that disrupt intestinal microorganisms are not herbivorous creatures but take the form of: Chlorinated/fluoridated drinking water—Municipal drinking water is chlorinated (and, more commonly today, chlorinated with the more persistent chloramine, not chlorine, that cannot be boiled off) to prevent bacterial and protozoal diseases, fluoridated on the (faulty) assumption that it prevents tooth decay, but these two potent halogenated antimi...
Publication date: August 2020Source: Journal of Functional Foods, Volume 71Author(s): Mohammad Zeinali Khosroshahi, Omid Asbaghi, Sajjad Moradi, Mahnaz Rezaei kelishadi, Mojtaba Kaviani, Mahnaz Mardani, Cyrus Jalili
Publication date: Available online 30 May 2020Source: Brain, Behavior, and ImmunityAuthor(s): Julie Lasselin, Sven Benson, Johannes Hebebrand, Karoline Boy, Vera Weskamp, Analena Handke, Till Hasenberg, Miriam Remy, Manuel Föcker, Meike Unteroberdörster, Alexandra Brinkhoff, Harald Engler, Manfred Schedlowski
Publication date: Available online 30 May 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Jia-Kang Wang, Tzu-Lun Huang, Pei-Yao Chang
Publication date: Available online 30 May 2020Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Mariola Bochniarz, Marek Szczubiał, Piotr Brodzki, Leszek Krakowski, Roman Dąbrowski
Publication date: Available online 30 May 2020Source: Molecular MetabolismAuthor(s): Veronika Leiss, Annika Schönsiegel, Thorsten Gnad, Johannes Kerner, Jyotsna Kaur, Tina Sartorius, Jürgen Machann, Fritz Schick, Lutz Birnbaumer, Hans-Ulrich Häring, Alexander Pfeifer, Bernd Nürnberg
Publication date: Available online 30 May 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Hema S. Gopalan, Anoop Misra
Publication date: Available online 30 May 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Sachin Atre, Sona Deshmukh, Manjusha Kulkarni
Publication date: 15 September 2020Source: Journal of Ethnopharmacology, Volume 259Author(s): Junnan Ma, Xianglong Meng, Yi Liu, Cheng Yin, Tong Zhang, Piao Wang, Yong-Ki Park, Hyo Won Jung
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Tian-Tian Liu, Xiao-Tian Liu, Qing-Xi Chen, Yan Shi
Osborne H Abstract The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, γ-glutamyl peptides, polyamines, polycationic peptides, and protons. The CaSR plays a critical role in extracellular calcium (Ca2+ o) homeostasis, as demonstrated by the many naturally occurring mutations in the CaSR or its signaling partners that cause Ca2+ o homeostasis disorders. However, CaSR tissue expression in mammals is broad and includes tissues unrelated to Ca2+ o homeostasis, ...
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