Inhibition of quorum sensing-controlled virulence factors of Pseudomonas aeruginosa by Murraya koenigii essential oil: a study in a Caenorhabditis elegans infectious model.

Inhibition of quorum sensing-controlled virulence factors of Pseudomonas aeruginosa by Murraya koenigii essential oil: a study in a Caenorhabditis elegans infectious model. J Med Microbiol. 2016 Nov 03;: Authors: Ganesh PS, Rai RV Abstract The global emergence of antibiotic resistant strains of Pseudomonas aeruginosa poses a major threat in hospital environments as well as in the community. P. aeruginosa is an opportunistic human pathogen and it also infects a wide range of model organisms including the nematode Caenorhabditis elegans. Quorum sensing (QS) mediates cell-to-cell communication in bacteria and has an important role in regulating virulence genes, antibiotic resistance and biofilm formation which are crucial for establishment of the infection. Expression of many virulence factors such as pyocyanin and proteases in P. aeruginosa is under the control of QS system which are mediated by small molecules such as acyl homoserine lactones (AHLs). Thus, interfering with the QS system would provide alternative ways of controlling the pathogenicity. Murraya koenigii is a medicinal plant widely used in India. The present study investigated the in vivo inhibitory activity of M. koenigii essential oil (EO) on QS-controlled virulence factors of P. aeruginosa PAO1 using C. elegans. The M. koenigii EO significantly inhibited the pyocyanin production and the staphylolytic LasA activity of P. aeruginosa PAO1. As compared to the control group...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research