Bacterial E3 ligase effectors exploit host ubiquitin systems.

Bacterial E3 ligase effectors exploit host ubiquitin systems.
Curr Opin Microbiol. 2016 Nov 28;35:16-22
Authors: Ashida H, Sasakawa C
Abstract
Ubiquitination is a crucial post-translational protein modification involved in regulation of various cellular processes in eukaryotes. In particular, ubiquitination is involved in multiple aspects of bacterial infection and host defense mechanisms. In parallel with the identification of ubiquitination as a component of host defense systems, recently accumulated evidence shows that many bacterial pathogens exploit host ubiquitin systems to achieve successful infection. Here, we highlight the strategies by which bacteria subvert host ubiquitin systems by mimicking E3 ubiquitin ligase activity.
PMID: 27907841 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - November 27, 2016 Category: Microbiology Authors: Ashida H, Sasakawa C Tags: Curr Opin Microbiol Source Type: research