Study of gene polymorphisms of glutathione s-transferase t1/m1 in egyptian children and adolescents with type 1 diabetes mellitus.

STUDY OF GENE POLYMORPHISMS OF GLUTATHIONE S-TRANSFERASE T1/M1 IN EGYPTIAN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS. J Clin Res Pediatr Endocrinol. 2016 Dec 02;: Authors: Barseem N, Elsamalehy M Abstract OBJECTIVE: To evaluate the association of glutathione S- transferase mu 1 (GST M1) and glutathione S- transferase theta 1 (GST T1) polymorphisms with the development of T1DM and disease-related risk factors. METHODS: Sixty-four diabetic children and 41 controls were enrolled and subjected to fasting glucose, serum creatinine, lipid profile, HbA1c and evaluation of GST T1 and M1 genetic polymorphisms using polymerase chain reaction (PCR). RESULTS: There were significantly higher fasting glucose, glycosylated hemoglobin (HbA1c) and cholesterol in the diabetics. GST T1 null genotype was more frequent in diabetic than the control group with 4.2 folds increased the risk of T1DM (OR=4.2; 95% CI=1.6-11.5; p=0.03). Significant positive association with the GST T1 deletion genotype with lipid profile, HbA1c, duration of illness but not with age, age at onset and body mass index. PMID: 27908841 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research